ATYR aTYR PHARMA INC
Executive Summary
6 major financial institutions (D.E. Shaw, Two Sigma, and 4 passive managers) collectively doubled or tripled their ATYR positions in 2025-Q3, though the aggregate dollar value declined sharply due to the stock's price collapse. 2 passive sellers exited near-completely. The cluster suggests coordinated acknowledgement of deep-value territory by quantitative and passive shops rather than fundamental conviction — consistent with the stock's ~60% analytical consensus bullishness but negative past-model calibration.
Key Financial Metrics
Institutional Positions
Net institutional flow: -$15.0M
▲ Buyers (7)
| Institution | Action | Change | Position Value | Value Δ |
|---|---|---|---|---|
| State Street | DOUBLED | +238.5% | $3.0M | -$3.3M |
| D.E. Shaw | DOUBLED | +445% | $60.0K | -$17.4K |
| Wellington Management Group | ADD | +34.6% | $209.0K | -$881.0K |
| UBS | DOUBLED | +158.1% | $3.2M | -$5.6M |
| Two Sigma | DOUBLED | +573.5% | $152.0K | -$6.6K |
| Morgan Stanley | DOUBLED | +173.2% | $512.0K | -$805.6K |
| BofA | DOUBLED | +319.6% | $128.0K | -$86.6K |
▼ Sellers (2)
| Institution | Action | Change | Prev Value | Value Δ |
|---|---|---|---|---|
| Wells Fargo | TRIM | -60% | $1.4M | -$1.3M |
| Invesco | NEAR_EXIT | -92.3% | $3.0M | -$3.0M |
Actionable Insight
The cluster is dominated by passive and quantitative managers — this is portfolio rebalancing and deep-value quant signals, not fundamental bullish conviction. The 60% consensus analyst rating (3SB/6B/6H) is far more bullish than this cluster's tone. Monitor for: (i) any fundamental catalyst (pipeline data, FDA interaction) that could re-rate the stock above current ~$46M market cap; (ii) whether any fundamental active manager appears in next quarter's 13F. With T+20 historical returns on this ticker averaging -5% and past model calibration showing net negative alpha at score 4-6, the risk/reward skew appears unfavorable near term.
Key Facts
- 7 buyers, 2 sellers in 2025-Q3
- Buyers added ~6.6M net shares vs sellers cutting ~718K shares
- Aggregate net buyer holdings $7.3M current vs original cost ~$18M — reflecting ~60% price decline
- D.E. Shaw +445% (15.3K→83.3K shares), Two Sigma +574% (31.3K→211.0K), UBS +158% (1.75M→4.51M)
- Invesco near-exit: sold 92% of its stake (598K→46K shares)
- All 7 buyers are quantitative or passive/index-type managers — no fundamental active manager or activist
Financial Impact
6 buyers accumulated net ~$7.3M in current value; 2 sellers disposed of ~$4.3M in prior value; net aggregate dollar decline of ~$15M due to share price drop
Risk Factors
- All buyers are passive/quant — no fundamental conviction signal
- Stock price decline means buyers are underwater on their Q3 positions
- Past model calls on ATYR have T+20 win rate of only 25% with avg -5.2% return — historical calibration suggests caution
- Invesco and Wells Fargo both reducing suggests continued institutional drift
Market Snapshot
Documents Analyzed
This report is based on 1 institutional 13F filing from SEC EDGAR.
| Document | Accession Number |
|---|---|
| INST-CLUSTER Data (Synthetic) | inst-cluster-ATYR-2025-Q3 |
Track record builds as more directional reports settle.
Filters
| Type | Now | ||||
|---|---|---|---|---|---|
|
Jun 11, 2026
1d ago
|
Institutional Cluster
| $0.4591 awaiting T+1 | awaiting T+1 | — | — |
|
Jun 8, 2026
4d ago
|
8-K
| $0.4430 awaiting T+1 | awaiting T+1 | — | — |
|
Jun 1, 2026
11d ago
|
8-K
| $0.5200 $0.5001 | ▼ −3.83% | ▼ −3.13% | — |
|
May 15, 2026
29d ago
|
8-K
| $0.5040 $0.5200 | ▲ +3.17% | ▲ +3.24% | — |
|
May 15, 2026
29d ago
|
Press Release
| $0.5040 $0.5200 | ▲ +3.17% | ▲ +3.24% | — |
|
May 11, 2026
4w ago
|
8-K
| $0.5300 $0.5300 | · 0.00% | ▼ −0.54% | — |
|
Mar 26, 2026
11w ago
|
DEFA14A
| $0.7520 $0.7310 | ▼ −2.79% | ▼ −2.43% | — |
|
Mar 5, 2026
14w ago
|
8-K
| $0.8240 $0.9000 | ▲ +9.22% | ▲ +8.38% | — |
|
Mar 5, 2026
14w ago
|
Press Release
| $0.8240 $0.9000 | ▲ +9.22% | ▲ +8.38% | — |
US Market Status
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