INKT MiNK Therapeutics
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Executive Summary
MiNK Therapeutics announced positive Phase II trial data for its agenT-797 cell therapy in combination with botensilimab and balstilimab in PD-1 refractory gastroesophageal cancer, showing a 77% disease control rate and improved survival with an induction strategy. Despite missing the primary endpoint of ORR, the durable responses and immune activation support further development. The data are being presented at AACR 2026.
Actionable Insight
The survival and immune reprogramming data may reframe clinical development strategy around sequencing and durability rather than response rate. Traders should monitor for upcoming trial expansions, partnership announcements, or FDA guidance on trial design for accelerated approval pathways.
Key Facts
- Phase II trial (n=17) showed 77% disease control rate (DCR) in PD-1 refractory gastroesophageal cancer patients.
- Induction strategy with agenT-797 led to median PFS of 6.9 months vs. 3.5 months (HR 0.19; p=0.015) and median OS of 9.5 vs. 5.2 months.
- 43% of induction-treated patients were alive at 12 and 18 months, compared to 20% and 0% in non-induction cohort.
- Trial did not meet primary endpoint of ORR, but durable disease control and survival are emphasized as key benefits.
- Biomarker analyses show immune activation, T-cell infiltration, and tertiary lymphoid structure formation.
Financial Impact
High clinical significance despite small sample size; potential to accelerate development and attract partnerships.
Risk Factors
- Small trial size (n=17) limits statistical power and generalizability.
- Primary endpoint (ORR) not met, which may raise skepticism among some investors.
- Safety profile includes immune-related adverse events such as colitis and hepatitis.
Market Snapshot
Documents Analyzed
This report is based on 1 press release from GlobeNewswire.
| Document | Accession Number |
|---|---|
| PRESS-RELEASE Data (Synthetic) | press-3276455 |
Filters
| Type | Now | ||||
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May 28, 2026
12d ago
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Press Release
| $12.20 $12.76 | ▲ +4.59% | ▲ +4.64% | $11.34 (−7.05%) |
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May 20, 2026
20d ago
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Press Release
| $10.72 $10.18 | ▼ −5.04% | ▼ −6.27% | $11.34 (+5.78%) |
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May 15, 2026
25d ago
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8-K
| $10.72 $10.87 | ▲ +1.40% | ▲ +0.44% | $11.34 (+5.78%) |
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May 15, 2026
25d ago
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Press Release
| $10.72 $10.87 | ▲ +1.40% | ▲ +0.44% | $11.34 (+5.78%) |
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May 14, 2026
26d ago
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Press Release
| $10.51 $10.94 | ▲ +4.09% | ▲ +4.81% | $11.34 (+7.90%) |
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May 12, 2026
28d ago
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Press Release
| $11.41 $10.04 | ▼ −12.01% | ▼ −12.08% | $11.34 (−0.61%) |
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May 8, 2026
4w ago
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Press Release
| $10.95 $10.04 | ▼ −8.31% | ▼ −8.23% | $11.34 (+3.56%) |
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Apr 17, 2026
7w ago
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Press Release
| $14.21 $10.95 | ▼ −22.94% | ▼ −23.50% | $11.34 (−20.20%) |
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Apr 1, 2026
9w ago
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Press Release
| $10.57 $11.47 | ▲ +8.51% | ▲ +4.75% | $11.34 (+7.28%) |
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Mar 31, 2026
10w ago
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8-K
| $10.53 $11.15 | ▲ +5.89% | ▲ +1.94% | $11.34 (+7.69%) |
US Market Status
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