KPTI Karyopharm Therapeutics Inc.
Price Chart
Executive Summary
Six KPTI insiders, including CEO Richard Paulson, sold shares on May 14 (the same day as Q1 earnings), totaling $35,000 in open-market sales. The dollar value is 0.02% of the $185M market cap — well below the 0.1% materiality floor. This is a routine cluster timed to a blackout-window opening, not an informed bearish signal. Separately, a director received a $0 grant of 15,508 shares on May 21 as non-cash compensation.
Key Financial Metrics
Actionable Insight
These sales are trivial and routine — ignore them. The real risk for KPTI is the $400M shelf registration (200%+ dilution) and cash runway ending late Q3 2026. Watch for an equity offering or partnership announcement as the financing catalyst, not insider trading patterns.
Key Facts
- Six insiders, including the CEO and CFO, sold shares on May 14 at $9.50, totaling $35,000.
- Sales represent 0.02% of $185M market cap — immaterial by all proportionality standards.
- Director Barry Greene received a 15,508-share $0 grant on May 21 (non-cash compensation).
- Sales occurred on earnings day (Q1 2026 results filed May 14), consistent with a blackout-window opening.
- Historical calibration shows cluster sell signals at this size have no predictive power for KPTI.
Financial Impact
Total insider sales of $35K, or ~0.02% of market cap; plus $0 non-cash grant
Risk Factors
- $400M shelf registration filed May 4 creates massive potential dilution (~200% of current market cap).
- Cash runway only extends into late Q3 2026 — acute financing risk constrains the stock.
- Phase 3 SENTRY myelofibrosis trial missed a co-primary endpoint, creating pipeline uncertainty.
Market Snapshot
Documents Analyzed
This report is based on 1 SEC document filed with EDGAR.
| Document | Accession Number |
|---|---|
| CLUSTER Data (Synthetic) | cluster-KPTI-1779826082813 |
Filters
| Type | Now | ||||
|---|---|---|---|---|---|
|
May 15, 2026
5w ago
|
Insider Cluster
| $7.14 $9.10 | ▲ +27.45% | ▲ +25.87% | $9.02 (+26.33%) |
|
May 15, 2026
5w ago
|
Insider Cluster
| $7.14 $9.10 | ▲ +27.45% | ▲ +25.87% | $9.02 (+26.33%) |
|
May 15, 2026
5w ago
|
Insider Cluster
| $7.14 $9.10 | ▼ −27.45% | ▼ −25.87% | $9.02 (−26.33%) |
|
May 15, 2026
5w ago
|
Insider Cluster
| $7.14 $9.10 | ▲ +27.45% | ▲ +25.87% | $9.02 (+26.33%) |
|
May 15, 2026
5w ago
|
Insider Cluster
| $7.14 $9.10 | ▼ −27.45% | ▼ −25.87% | $9.02 (−26.33%) |
|
May 15, 2026
5w ago
|
EFFECT
| $7.67 $9.64 | ▼ −25.68% | ▼ −23.57% | $9.02 (−17.60%) |
|
May 14, 2026
5w ago
|
8-K
| $8.90 $9.50 | ▲ +6.74% | ▲ +7.60% | $9.02 (+1.35%) |
|
May 4, 2026
6w ago
|
S-3
| $9.41 $9.23 | ▼ −1.91% | ▼ −6.87% | $9.02 (−4.14%) |
|
May 4, 2026
6w ago
|
S-3
| $9.41 $9.23 | ▲ +1.91% | ▲ +6.87% | $9.02 (+4.14%) |
|
Mar 3, 2026
15w ago
|
8-K
| $9.13 $5.57 | ▲ +38.99% | ▲ +34.59% | $9.02 (+1.20%) |
US Market Status
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