NTLA Intellia Therapeutics, Inc.
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Executive Summary
Intellia Therapeutics reported its Q4 and full-year 2025 financial results, highlighting a reduction in net loss to $95.8 million from $128.9 million in Q4 2024, driven by lower R&D expenses. The company maintains a strong cash position of $605.1 million, sufficient to fund operations into mid-2027. Key clinical developments include advancing its lonvo-z program for HAE with Phase 3 data expected by mid-2026 and resolving the clinical hold for the MAGNITUDE-2 trial of nex-z for ATTRv-PN, while ongoing discussions with the FDA continue regarding the hold on the MAGNITUDE trial for ATTR-CM.
Key Financial Metrics
Actionable Insight
Traders should monitor the upcoming topline data from the HAELO Phase 3 trial by mid-2026, which could be a significant catalyst. The resolution of the clinical hold for the MAGNITUDE-2 trial is positive, but the ongoing hold on the MAGNITUDE trial for ATTR-CM remains a key risk. The improved financials and cash runway provide near-term stability.
Key Facts
- Net loss decreased to $95.8 million in Q4 2025 from $128.9 million in Q4 2024.
- Cash, cash equivalents, and marketable securities totaled $605.1 million as of December 31, 2025.
- R&D expenses decreased to $88.7 million in Q4 2025 from $116.9 million in Q4 2024.
- Collaboration revenue increased to $23.0 million in Q4 2025 from $12.9 million in Q4 2024.
- Clinical hold on the MAGNITUDE-2 trial for nex-z in ATTRv-PN was lifted on January 27, 2026.
- FDA engagement is ongoing to resolve the clinical hold on the MAGNITUDE trial for nex-z in ATTR-CM.
- Topline data from the HAELO Phase 3 trial for lonvo-z in HAE is expected by mid-2026.
Financial Impact
Net loss improved by $33.1 million in Q4 2025, with cash burn decreasing due to lower R&D spend. Collaboration revenue increased by $10.1 million YoY.
Segment Breakdown
| Segment | Revenue | Growth |
|---|---|---|
| Collaboration | $23.0M | +78.4% |
Risk Factors
- Ongoing clinical hold on the MAGNITUDE trial for nex-z in ATTR-CM could delay development and impact investor sentiment.
- The success of the lonvo-z program is critical, and any negative data from the HAELO Phase 3 trial could significantly impact the stock.
- The company remains in a pre-revenue stage, dependent on clinical trial outcomes and future funding.
Market Snapshot
Documents Analyzed
This report is based on 5 SEC documents filed with EDGAR.
| Document | Accession Number |
|---|---|
| 8-K Filing (Primary) | 0001193125-26-073456 |
| Document: ntla-20260226.htm | 0001193125-26-073456 |
| Document: 0001193125-26-073456-index-headers.html | 0001193125-26-073456 |
| Document: 0001193125-26-073456-index.html | 0001193125-26-073456 |
| Document: 0001193125-26-073456.txt | 0001193125-26-073456 |
Filters
| Type | Now | ||||
|---|---|---|---|---|---|
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Jun 13, 2026
today
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Press Release
| — | awaiting T+5 | — | — |
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Jun 1, 2026
12d ago
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Press Release
| $13.73 $13.54 | ▼ −1.38% | ▲ +1.37% | $12.11 (−11.80%) |
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May 11, 2026
4w ago
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8-K
| $14.42 $12.69 | ▼ −12.00% | ▼ −11.91% | $12.11 (−16.02%) |
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Apr 27, 2026
6w ago
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Press Release
| $13.20 $13.87 | ▼ −5.08% | ▼ −3.38% | $12.11 (+8.26%) |
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Apr 27, 2026
6w ago
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8-K
| $13.04 $13.87 | ▲ +6.37% | ▲ +5.96% | $12.11 (−7.13%) |
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Apr 3, 2026
10w ago
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Press Release
| $13.30 $14.26 | ▲ +7.22% | ▲ +3.08% | $12.11 (−8.95%) |
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Mar 6, 2026
14w ago
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Press Release
| $13.89 $13.38 | ▼ −3.67% | ▼ −2.32% | $12.11 (−12.81%) |
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Mar 2, 2026
14w ago
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Press Release
| $15.44 $13.89 | ▼ −10.04% | ▼ −8.83% | $12.11 (−21.57%) |
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Mar 2, 2026
14w ago
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Insider Cluster
| $15.44 $13.89 | ▼ −10.04% | ▼ −8.83% | $12.11 (−21.57%) |
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Feb 28, 2026
15w ago
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Institutional Cluster
| $15.44 $13.89 | ▼ −10.04% | ▼ −8.83% | $12.11 (−21.57%) |
US Market Status
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