SYRE Spyre Therapeutics, Inc.

NEUTRAL Impact: 3/10 EFFECT
Horizon weeks Filed Mar 2, 2026 Processed 3mo ago SEC 9999999995-26-000695
IPO/offering going effective
Final — all horizons settled through T+60d
SYRE ▲ +73.33% at T+60d
NEUTRAL call ✓ call won +73.33% · α vs SPY +64.01% · entry $42.49 → $73.65
Last close $72.00 (close Jun 8) · +69.45% from $42.49 entry
Entry anchored
Feb 27, 03:59 PM ET
via Databento tick
T+1d
-5.70%
call -5.70% · α -4.78%
$40.07
settled 3mo ago
T+5d
-3.34%
call -3.34% · α -2.13%
$41.07
settled 3mo ago
T+20d
+6.90%
call +6.90% · α +14.83%
$45.42
settled 2mo ago
T+60d
+73.33%
call +73.33% · α +64.01%
$73.65
settled 14d ago

Price Chart

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Executive Summary

Spyre Therapeutics' shelf registration (Form S-3) has become effective, allowing the company to issue unspecified securities from time to time. This is a routine capital markets update with no immediate financial impact.

Actionable Insight

Monitor for future prospectus supplements that will disclose actual offering terms, timing, and size. Shelf registrations allow flexibility but create potential dilution overhang.

Key Facts

  • Form EFFECT filed for Spyre Therapeutics, Inc. (SYRE)
  • Effectiveness date: February 27, 2026
  • Underlying registration is Form S-3 (shelf registration)
  • No specific offering size, pricing, or securities type disclosed
  • Company previously known as Aeglea BioTherapeutics, Inc.

Financial Impact

Not specified

dilutioncapital_structure

Risk Factors

  • Future issuance could lead to shareholder dilution
  • Market perception of equity overhang may pressure stock price

Market Snapshot

Exchange
Nasdaq

Documents Analyzed

This report is based on 3 SEC documents filed with EDGAR.

DocumentAccession Number
EFFECT Filing (Primary)9999999995-26-000695
Document: 9999999995-26-000695-index.html9999999995-26-000695
Document: 9999999995-26-000695.txt9999999995-26-000695
16 reports for SYRE
Performance horizon
83% Hit rate 5 of 6 directional calls best @ T+20▲ +20.80%Apr 13, 2026
Filters
Rows
Reports for SYRE — sortable, filterable
Type Now
Jun 4, 2026
6d ago
Insider Cluster
NEUTRAL ★ 2/10
$78.48 $73.65▼ −6.15%▼ −3.56%$72.00 (−8.26%)
Jun 1, 2026
8d ago
8-K
BULLISH ★ 7/10
$69.16 $73.52▲ +6.30%▲ +7.00%$72.00 (+4.11%)
May 29, 2026
11d ago
8-K
NEUTRAL ★ 3/10
$70.54 $69.16▼ −1.96%▼ −2.10%$72.00 (+2.07%)
May 5, 2026
5w ago
8-K
MIXED ★ 6/10
$71.01 $73.00▲ +2.80%▲ +1.42%$72.00 (+1.39%)
May 1, 2026
5w ago
Insider Cluster
NEUTRAL ★ 3/10
$69.42 $69.13▼ −0.42%▼ −0.08%$72.00 (+3.72%)
May 1, 2026
5w ago
Insider Cluster
NEUTRAL ★ 2/10
$69.42 $69.13▼ −0.42%▼ −0.08%$72.00 (+3.72%)
Apr 15, 2026
8w ago
Press Release
NEUTRAL ★ 6/10
$68.99 $69.70▲ +1.03%▲ +0.78%$72.00 (+4.36%)
Apr 13, 2026
8w ago
424B5
BULLISH ★ 8/10
$64.01 $68.99▲ +7.78%▲ +7.01%$72.00 (+12.48%)
Apr 13, 2026
8w ago
Press Release
BEARISH ★ 7/10
$64.01 $68.99▼ −7.78%▼ −7.01%$72.00 (−12.48%)
Apr 13, 2026
8w ago
8-K
NEUTRAL ★ 5/10
$64.01 $68.99▲ +7.78%▲ +7.01%$72.00 (+12.48%)
Showing 10 of 16

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