TNYA Tenaya Therapeutics, Inc.

BULLISH Impact: 1/10 ANALYST-UPGRADE
Processed 24d 10h ago SEC analyst-TNYA-williamb-20240610
William Blair initiates coverage on TNYA at Outperform
Final — all horizons settled through T+60d
TNYA ▼ -35.64% at T+60d
LONG call ✗ call lost -35.64% · α vs SPY -38.24% · entry $3.76 → $2.42
Last close $0.6860 (close Jun 8) · -81.76% from $3.76 entry
Entry anchored
Jun 10, 11:28 AM ET
via Databento tick
T+1d
-1.86%
call -1.86% · α -2.10%
$3.69
settled 24mo ago
T+5d
-12.23%
call -12.23% · α -14.36%
$3.30
settled 24mo ago
T+20d
-18.35%
call -18.35% · α -23.14%
$3.07
settled 23mo ago
T+60d
-35.64%
call -35.64% · α -38.24%
$2.42
settled 21mo ago

Price Chart

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Executive Summary

William Blair initiated coverage on Tenaya Therapeutics (TNYA) at Outperform with no price target, joining a consensus that is already 93% Buy/Strong Buy (13 of 14 analysts). The stock trades at $0.94, a 78% discount to the $4.20 mean target and 89% below the $8 high target. William Blair's track record is average at 51% accuracy on 273 calls with a +4.2% average return. Recent EPS revisions have been strongly positive — the 0-year estimate improved from -$0.43 to -$0.39 over 30 days, and the current quarter estimate improved from -$0.11 to -$0.06. Insider selling is notable: Column Group III GP, LP sold ~$1.36M in late February 2026, though this is a large holder, not C-suite. Short interest is elevated at 56% of TRF volume, indicating heavy bearish positioning. The initiation adds no new price target or contrarian view, making it a low-impact confirmation of an already crowded bullish consensus.

Impact Score

Base Score
1/7
LLM Adjustment
-1
Final Score
1/10

Consensus & Targets

Buy / Strong Buy
13 (93%)
Hold
1
Sell / Strong Sell
0
Total Analysts
5
Mean PT
$4.20
Median PT
$3.00
High PT
$8.00
Low PT
$2.00
Current Price
$0.9350
Implied Upside
+349.2%

Of 14 analysts covering TNYA: 4 Strong Buy (29%), 9 Buy (64%), 1 Hold (7%), 0 Sell, 0 Strong Sell. Consensus is overwhelmingly bullish at 93% Buy/Strong Buy.

Current price: $0.935. Mean target: $4.20 (implied upside +349%). Median: $3.00. High: $8.00. Low: $2.00. William Blair did not set a price target, so its view sits below the consensus mean/median in terms of specificity.

Recent Analyst Activity

DateFirmActionRatingPrice Target
2026-03-12 Chardan Capital maintain Buy
2025-12-18 Canaccord Genuity maintain Buy $5.00
2025-12-12 HC Wainwright & Co. maintain Buy $3.00
2025-12-12 Chardan Capital maintain Buy $8.00
2025-11-10 Chardan Capital maintain Buy $9.00
2025-09-02 HC Wainwright & Co. reiterate Buy $5.00
2025-08-27 HC Wainwright & Co. reiterate Buy $5.00
2025-08-07 Chardan Capital maintain Buy $9.00
2025-05-09 Chardan Capital maintain Buy $9.00
2025-04-25 HC Wainwright & Co. reiterate Buy $5.00

30-day analyst activity: 0 upgrades, 0 downgrades. EPS revision trend is strongly positive: 0-year EPS revised from -$0.43 to -$0.39 (up 4 revisions, 0 down); current quarter EPS revised from -$0.11 to -$0.06 (up 1 revision, 0 down). Estimates are being revised higher across all periods.

Firm Track Record — William Blair

William Blair accuracy: 51% on 273 calls | avg return: 4.2%

Industry benchmark: mean 51% ± 11%. Top tier: ≥61% (mean + 1σ). Based on 3 firms with ≥5 scored calls.

FirmAccuracyCallsAvg Returnvs Average
Chardan Capital 57% 4/7 1.3% above average
HC Wainwright & Co. 43% 6/14 -18.8% below average
Canaccord Genuity 25% 1/4 -13% below average

William Blair has 51% accuracy on 273 calls with +4.2% average return — slightly above the average of covering firms. Among peers: Chardan Capital leads at 57% (7 calls), HC Wainwright at 43% (14 calls, -18.8% avg return), Canaccord Genuity at 25% (4 calls, -13% avg return). William Blair is the most active firm on this ticker by total calls.

Earnings Estimates

PeriodEPS Est.EPS RangeRevenueRevisions (7d)
+1y $-0.42 $-0.59 — $-0.29 $0.00 ↑0 ↓0
0y $-0.39 $-0.59 — $-0.27 $10.2M ↑4 ↓0
+1q $-0.10 $-0.14 — $-0.08 $0.00 ↑4 ↓0
0q $-0.06 $-0.14 — $-0.09 $0.00 ↑1 ↓0

Cross-Platform Signals

Insider Trades (90d)
0 buys / 5 sells
Institutional
VANGUARD GROUP INC — add (69%)
Institutional
WELLS FARGO & COMPANY/MN — doubled (300%)
Institutional
TWO SIGMA INVESTMENTS, LP — add (39%)
Short Interest
Short: 4,283,484 | Exempt: 64,221 | TRF Vol: 7,645,666 | Short Ratio: 56.0% | Off-exchange volume (dark pool + OTC)

Insider selling: Column Group III GP, LP sold ~$1.36M in late February 2026 (non-C-suite, large holder). No C-suite trades. Institutional activity is bullish: Vanguard added 69% ($6.1M), Wells Fargo doubled (+300%), Two Sigma added 39%, Morgan Stanley added 44%. Short interest is elevated at 56% of TRF volume, indicating heavy bearish positioning that could fuel a squeeze. Signal convergence: bullish analyst consensus + institutional accumulation + improving EPS revisions vs. bearish short interest and insider selling by a large holder.

Actionable Insight

This initiation is a low-conviction confirmation of an already crowded bullish consensus. The real signal is the improving EPS revisions and heavy institutional buying — but the 56% short interest and insider selling warrant caution. Wait for a price target or a catalyst before adding.

Documents Analyzed

Report based on filing metadata.

9 reports for TNYA
Performance horizon

Track record builds as more directional reports settle.

Filters
Rows
Reports for TNYA — sortable, filterable
Type Now
May 29, 2026
11d ago
8-K
NEUTRAL ★ 3/10
$0.8700 $0.7280▼ −16.32%▼ −13.57%$0.6860 (−21.15%)
May 19, 2026
21d ago
Insider Cluster
NEUTRAL ★ 2/10
$0.8080 $0.7920▼ −1.98%▼ −3.22%$0.6860 (−15.10%)
May 16, 2026
24d ago
ANALYST-UPGRADE
BULLISH ★ 1/10
$3.76 $3.30▼ −12.23%▼ −14.36%$0.6860 (−81.76%)
Apr 16, 2026
7w ago
ANALYST-UPGRADE
MIXED ★ 1/10
$0.7820 $0.6720▼ −14.07%▼ −14.62%$0.6860 (−12.28%)
Apr 16, 2026
7w ago
DEFA14A
NEUTRAL ★ 3/10
$0.7470 $0.6840▼ −8.43%▼ −9.42%$0.6860 (−8.17%)
Mar 11, 2026
12w ago
8-K
NEUTRAL ★ 4/10
$0.8930 $0.8040▼ −9.97%▼ −8.99%$0.6860 (−23.18%)
Mar 11, 2026
12w ago
Press Release
MIXED ★ 6/10
$0.8930 $0.8040▼ −9.97%▼ −8.99%$0.6860 (−23.18%)
Mar 9, 2026
13w ago
Press Release
BULLISH ★ 7/10
$0.9580 $0.8570▼ −10.54%▼ −9.19%$0.6860 (−28.39%)
Mar 5, 2026
13w ago
8-K
BULLISH ★ 8/10
$0.8190 $0.8930▲ +9.04%▲ +11.27%$0.6860 (−16.24%)
Showing 9 of 9

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