ALNY

ALNYLAM PHARMACEUTICALS, INC.

Nasdaq · Pharmaceutical Preparations · CIK 0001178670
$282.85 -2.26% $37.8B
Insider Selling Cluster (5 insiders)High Impact Filing (7/10)30 New Institutional Positions20 Institutional Exits
Vol
Market Cap$37.8B
Cap SizeLarge Cap
Analyst ConsensusStrong Buy (76%)
Inst. Holders50 funds
Inst. Value$29.9B
Inst. Activity30 buys / 20 sells
Insider Activity0B / 15S
Insider Net $-$3.0M
SEC Reports3
Exchange Nasdaq·Sector Pharmaceutical Preparations·CIK 0001178670·Prev Close $289.39

Recent Activity

Jun 12, 2026 short_volume
Short Volume: ALNY — 55.6% short (0.4M / 0.7M)
Short: 390,444 | Exempt: 938 | TRF Vol: 701,645 | Short Ratio: 55.6% | Off-exchange volume (dark poo
Jun 1, 2026 Insider
PYOTT DAVID E I sold 921 shares
Director @ $297.71 ($274.2K)
Jun 1, 2026 Insider
PYOTT DAVID E I acquired via exercise 3,830 shares
Director
Jun 1, 2026 Insider
Cravatt Benjamin was granted 4,393 shares
Director
Mar 6, 2026 SEC
Seven Alnylam Pharmaceuticals insiders executed trades over the past week, with three C-suite executives selling a combi
CLUSTER — Impact 3/10
Mar 5, 2026 SEC
A cluster of insider transactions at Alnylam Pharmaceuticals over the past week includes open-market sales by the CSO an
CLUSTER — Impact 3/10
Feb 28, 2026 SEC
Three major institutions, including sovereign wealth fund Norges Bank, accumulated $1.06B in new positions in Alnylam Ph
INST-CLUSTER — Impact 7/10
Inst.
Capital World Investors — TRIM
10,802,348 shares ($3.6B)

Price Targets

$438.52 +55.0% upside Strong Buy
Current $282.85 Low $310.00 Median $429.00 High $550.00 25 analysts
$310.00 $550.00

Analyst Ratings

Buy76% buy · 37 analysts
7Strong Buy
21Buy
9Hold
0Sell
0Strong Sell
Recent Analyst Actions
DateFirmActionRating
Jun 4, 2026 HC Wainwright & Co. REITERATE Buy → Buy
May 19, 2026 Citigroup INITIATE Buy
May 5, 2026 HC Wainwright & Co. REITERATE Buy → Buy
May 1, 2026 RBC Capital MAINTAIN Outperform → Outperform
May 1, 2026 Wells Fargo MAINTAIN Equal-Weight → Equal-Weight

Earnings Estimates

PeriodEPS Est.RangeGrowth#
Current Q $2.17 ▲ +4.8% $1.65 — $3.49 577% YoY 14
Next Q $2.46 ▲ +3.8% $1.53 — $3.74 -15% YoY 14
Current FY $9.50 ▲ +1.9% $7.94 — $13.00 87% YoY 16
Next FY $13.77 $11.10 — $18.21 45% YoY 16

Top Institutional Holders

FundValueMove
FMR LLC$4.8B
Capital World Investors$3.6BTRIM
BlackRock, Inc.$3.5B
Capital Research Global Investors$3.1BADD
VANGUARD PORTFOLIO MANAGEMENT LLC$2.1B

Recent Insider Trades

DateInsiderTypeValue
Jun 1, 2026PYOTT DAVIDSELL$274.2K
Jun 1, 2026PYOTT DAVIDM$0.00
Jun 1, 2026Cravatt BenjaminA$0.00
May 20, 2026Arbuckle StuartA$0.00
May 20, 2026Arbuckle StuartA$0.00
50 institutional holders with $29.9B total value (90,536,242 shares) as of 2026-Q1. Top holders: FMR, Capital, BlackRock,. Net buying activity: 30 institutions added/increased vs 20 reduced.

Top Institutional Holders — 2026-Q1

#FundSharesValue% of TrackedLast Move
1FMR LLC14,579,166$4.8B16.1%
2Capital World Investors10,802,348$3.6B11.9%TRIM -33.7%
3BlackRock, Inc.10,444,908$3.5B11.5%
4Capital Research Global Investors9,471,181$3.1B10.5%ADD +39.7%
5VANGUARD PORTFOLIO MANAGEMENT LLC6,491,280$2.1B7.2%
6VANGUARD CAPITAL MANAGEMENT LLC5,946,706$2.0B6.6%
7STATE STREET CORP3,322,698$1.1B3.7%
8BAILLIE GIFFORD & CO2,493,866$825.1M2.8%
9TWO SIGMA INVESTMENTS, LP1,992,577$659.3M2.2%
10WELLINGTON MANAGEMENT GROUP LLP1,935,925$640.5M2.1%
11DODGE & COX1,929,253$638.3M2.1%
12Clearbridge Investments, LLC1,356,036$448.7M1.5%DOUBLED +127.1%
13Invesco Ltd.1,291,726$427.4M1.4%TRIM -40.4%
14MARSHALL WACE, LLP1,099,318$363.7M1.2%ADD +99.9%
15D. E. Shaw & Co., Inc.1,059,062$350.4M1.2%
16MORGAN STANLEY1,002,681$331.8M1.1%
17BANK OF AMERICA CORP /DE/966,912$319.9M1.1%ADD +41.1%
18Legal & General Group Plc934,881$309.3M1.0%
19VANGUARD FIDUCIARY TRUST CO840,888$278.2M0.9%
20ROYAL BANK OF CANADA791,515$261.9M0.9%

Recent Position Changes

FundActionPrev SharesCurr SharesChange %ValueQuarter
Capital World InvestorsTRIM16,301,77210,802,348-33.7%$3.6B2026-Q1
Capital Research Global InvestorsADD6,779,7089,471,181+39.7%$3.1B2026-Q1
Clearbridge Investments, LLCDOUBLED597,0131,356,036+127.1%$448.7M2026-Q1
Invesco Ltd.TRIM2,165,8401,291,726-40.4%$427.4M2026-Q1
MARSHALL WACE, LLPADD549,9221,099,318+99.9%$363.7M2026-Q1
BANK OF AMERICA CORP /DE/ADD685,177966,912+41.1%$319.9M2026-Q1
MANUFACTURERS LIFE INSURANCE COMPANY, THEDOUBLED63,412662,365+944.5%$219.2M2026-Q1
FRANKLIN RESOURCES INCTRIM787,623470,390-40.3%$155.6M2026-Q1
DIMENSIONAL FUND ADVISORS LPADD301,865384,205+27.3%$127.1M2026-Q1
FIRST TRUST ADVISORS LPADD256,954382,701+48.9%$126.6M2026-Q1
Nuveen, LLCTRIM565,789322,232-43.0%$106.6M2026-Q1
PINEBRIDGE INVESTMENTS LLCDOUBLED100,199271,419+170.9%$89.8M2026-Q1
Woodline Partners LPDOUBLED1,759243,883+13764.9%$80.7M2026-Q1
AMERIPRISE FINANCIAL INCADD181,137239,941+32.5%$79.4M2026-Q1
BNP Paribas Asset Management Holding S.A.ADD109,604180,012+64.2%$59.6M2026-Q1
ENVESTNET ASSET MANAGEMENT INCADD120,521171,797+42.5%$56.8M2026-Q1
VOYA INVESTMENT MANAGEMENT LLCTRIM198,613148,488-25.2%$49.1M2026-Q1
CAPITAL FUND MANAGEMENT S.A.DOUBLED20,940140,109+569.1%$46.4M2026-Q1
Assenagon Asset Management S.A.DOUBLED25,590128,896+403.7%$42.6M2026-Q1
LOS ANGELES CAPITAL MANAGEMENT LLCTRIM240,05288,278-63.2%$29.2M2026-Q1
LMR Partners LLPADD59,02274,661+26.5%$24.7M2026-Q1
NEOS Investment Management LLCADD40,70168,873+69.2%$22.8M2026-Q1
Trexquant Investment LPDOUBLED26,74161,760+131.0%$20.4M2026-Q1
PFA Pension, ForsikringsaktieselskabADD35,40559,700+68.6%$19.8M2026-Q1
STIFEL FINANCIAL CORPDOUBLED20,42749,954+144.5%$16.5M2026-Q1
16 unique insiders with 50 transactions. Net insider value: -$3.0M ($0.00 bought, $3.0M sold).

Insider Transactions

DateInsiderTitleTypeSharesPriceValue
Jun 1, 2026PYOTT DAVID E IDirectorSELL921$297.71$274.2K
Jun 1, 2026PYOTT DAVID E IDirectorEXERCISE3,830
Jun 1, 2026Cravatt BenjaminDirectorAWARD4,393
May 20, 2026Arbuckle Stuart ADirectorAWARD671
May 20, 2026Arbuckle Stuart ADirectorAWARD1,441
May 20, 2026BRANDICOURT OLIVIERDirectorAWARD1,441
May 20, 2026Ausiello Dennis ADirectorAWARD1,441
May 20, 2026Ausiello Dennis ADirectorAWARD671
May 20, 2026BRANDICOURT OLIVIERDirectorAWARD671
May 20, 2026HAMBURG MARGARET ADirectorAWARD671
May 20, 2026HAMBURG MARGARET ADirectorAWARD1,441
May 20, 2026KELLOGG PETER NDirectorAWARD671
May 20, 2026KELLOGG PETER NDirectorAWARD1,441
May 20, 2026PYOTT DAVID E IDirectorAWARD1,441
May 20, 2026PYOTT DAVID E IDirectorAWARD671
May 20, 2026Sigal Charles ElliottDirectorAWARD1,441
May 20, 2026Reitan Colleen FDirectorAWARD1,441
May 20, 2026Reitan Colleen FDirectorAWARD671
May 20, 2026SCHULMAN AMY WDirectorAWARD838
May 20, 2026SCHULMAN AMY WDirectorAWARD1,802
May 20, 2026Sigal Charles ElliottDirectorAWARD671
May 13, 2026SCHULMAN AMY WDirectorEXERCISE11,250$70.20$789.8K
Apr 6, 2026McLaughlin MelissaChief Human Resources OfficerSELL56$320.14$17.9K
Apr 2, 2026McLaughlin MelissaChief Human Resources OfficerSELL265$316.61$83.9K
Mar 5, 2026Garg PushkalEVP Chief R&DSELL654$322.33$210.8K
Mar 5, 2026Fitzgerald Kevin JosephCSO & EVP, Head of ResearchSELL124$321.81$39.9K
Mar 4, 2026Greenstreet YvonneChief Executive OfficerSELL135$319.03$43.1K
Mar 4, 2026Tanguler TolgaEVP, Chief Commercial OfficerSELL106$319.03$33.8K
Mar 4, 2026Fitzgerald Kevin JosephCSO & EVP, Head of ResearchSELL29$319.03$9.3K
Mar 4, 2026Poulton Jeffrey V.EVP, Chief Financial OfficerSELL114$319.03$36.4K
Mar 4, 2026Garg PushkalEVP Chief R&DSELL106$319.03$33.8K
Mar 3, 2026Garg PushkalEVP Chief R&DSELL355$316.74$112.4K
Mar 3, 2026Fitzgerald Kevin JosephCSO & EVP, Head of ResearchSELL289$316.55$91.5K
Mar 2, 2026Poulton Jeffrey V.EVP, Chief Financial OfficerAWARD4,769
Mar 2, 2026Greenstreet YvonneChief Executive OfficerAWARD30,425
Mar 2, 2026Greenstreet YvonneChief Executive OfficerAWARD110,746
Mar 2, 2026Greenstreet YvonneChief Executive OfficerAWARD13,844
Mar 2, 2026Poulton Jeffrey V.EVP, Chief Financial OfficerAWARD10,480
Mar 2, 2026Garg PushkalEVP Chief R&DAWARD4,769
Mar 2, 2026Garg PushkalEVP Chief R&DAWARD10,480
Mar 2, 2026Fitzgerald Kevin JosephCSO & EVP, Head of ResearchAWARD3,688
Mar 2, 2026Fitzgerald Kevin JosephCSO & EVP, Head of ResearchAWARD8,105
Feb 27, 2026Poulton Jeffrey V.EVP, Chief Financial OfficerEXERCISE1,908
Feb 27, 2026Tanguler TolgaEVP, Chief Commercial OfficerEXERCISE1,666
Feb 27, 2026Greenstreet YvonneChief Executive OfficerEXERCISE5,921
Feb 27, 2026Garg PushkalEVP Chief R&DEXERCISE1,908
Feb 23, 2026Fitzgerald Kevin JosephCSO & EVP, Head of ResearchAWARD158
Feb 17, 2026Fitzgerald Kevin JosephCSO & EVP, Head of ResearchSELL2,041$331.96$677.5K
Feb 13, 2026Poulton Jeffrey V.EVP, Chief Financial OfficerSELL2,242$310.08$695.2K
Feb 13, 2026Tanguler TolgaEVP, Chief Commercial OfficerSELL1,959$310.08$607.4K

No press releases analyzed yet. Press releases are collected from GlobeNewsWire and analyzed by the LLM pipeline.

Current analyst consensus: Buy (76% buy). Based on 37 analysts: 7 strong buy, 21 buy, 9 hold, 0 sell, 0 strong sell.

Analyst Price Targets

$438.52 mean target +55.0% upside Strong Buy (1.79)
$310.00 Low $550.00 High
MetricValue
Current Price$282.85
Target Low$310.00
Target Mean$438.52
Target Median$429.00
Target High$550.00
# Analysts25
RecommendationStrong Buy (1.79)

Earnings Estimates & Revisions

PeriodEPS AvgEPS LowEPS HighEPS Growth30d Rev.Up/DownRev. AvgRev. GrowthAnalysts
Current Q
2026-06-30
$2.17 $1.65 $3.49 576.7% +4.8% 3↑ 8↓ $1.3B 70.8% 14
Next Q
2026-09-30
$2.46 $1.53 $3.74 -15.1% +3.8% 1↑ 10↓ $1.5B 18.5% 14
Current FY
2026-12-31
$9.50 $7.94 $13.00 87.1% +1.9% 7↑ 6↓ $5.6B 51.5% 16
Next FY
2027-12-31
$13.77 $11.10 $18.21 44.8% -0.2% 4↑ 9↓ $7.3B 30.2% 16

Current Quarter EPS Revision History

TimepointEPS EstimateChange
Current$2.165
7d ago$2.165
30d ago$2.066+0.100
60d ago$2.136+0.029
90d ago$2.181-0.016
14 analyst firms have rated this stock: 1 upgrades, 1 downgrades, 2 initiations.

Individual Analyst Actions

DateAnalyst FirmActionPrevious RatingNew Rating
Jun 4, 2026 HC Wainwright & Co. REITERATE Buy Buy
May 19, 2026 Citigroup INITIATE Buy
May 5, 2026 HC Wainwright & Co. REITERATE Buy Buy
May 1, 2026 RBC Capital MAINTAIN Outperform Outperform
May 1, 2026 Wells Fargo MAINTAIN Equal-Weight Equal-Weight
Apr 13, 2026 Truist Securities MAINTAIN Buy Buy
Mar 25, 2026 Chardan Capital MAINTAIN Buy Buy
Mar 25, 2026 HC Wainwright & Co. REITERATE Buy Buy
Mar 16, 2026 Jefferies DOWNGRADE Buy Hold
Feb 18, 2026 HC Wainwright & Co. REITERATE Buy Buy
Feb 17, 2026 Freedom Broker UPGRADE Hold Buy
Feb 17, 2026 Canaccord Genuity MAINTAIN Buy Buy
Feb 13, 2026 Chardan Capital MAINTAIN Buy Buy
Feb 12, 2026 Needham MAINTAIN Buy Buy
Jan 30, 2026 Morgan Stanley MAINTAIN Equal-Weight Equal-Weight
Jan 30, 2026 B of A Securities MAINTAIN Buy Buy
Jan 30, 2026 HC Wainwright & Co. MAINTAIN Buy Buy
Jan 28, 2026 Barclays INITIATE Overweight
Jan 20, 2026 RBC Capital MAINTAIN Outperform Outperform
Jan 20, 2026 Wells Fargo MAINTAIN Equal-Weight Equal-Weight
Jan 12, 2026 B of A Securities MAINTAIN Buy Buy
Jan 12, 2026 Needham MAINTAIN Buy Buy
Jan 8, 2026 Truist Securities MAINTAIN Buy Buy
Dec 15, 2025 Leerink Partners MAINTAIN Market Perform Market Perform

Monthly Consensus History

PeriodStrong BuyBuyHoldSellStrong SellBuy %Distribution
Jun 1, 202672190076%
May 1, 202672090075%
Apr 1, 202672090075%
Mar 1, 202682080078%
Feb 1, 202681990075%
Jan 1, 202681990075%
Strong BuyBuyHoldSellStrong Sell

No congressional trading data available for this ticker. Data is sourced from Senate and House financial disclosure filings.

No Reddit sentiment data available yet. Sentiment is analyzed from Reddit investment communities on a rolling basis.

Jun 12, 2026
short_volume
Short Volume: ALNY — 55.6% short (0.4M / 0.7M)
Short: 390,444 | Exempt: 938 | TRF Vol: 701,645 | Short Ratio: 55.6% | Off-exchange volume (dark pool + OTC)
May 18, 2026
dark_pool
Dark Pool: ALNY — 1.0M shares, 49,330 trades
Week starting 2026-05-18. Total ATS volume: 970,996 shares across 49,330 trades.
May 12, 2026
short_interest
FTD: ALNY — 18,560 shares ($5.3M) failed to deliver
Settlement: 20260512, Price: $284.84, FTD Value: $5,286,630.4, ALYNLAM PHARMACEUTICALS INC
May 11, 2026
dark_pool
Dark Pool: ALNY — 1.5M shares, 54,875 trades
Week starting 2026-05-11. Total ATS volume: 1,488,504 shares across 54,875 trades.
May 4, 2026
dark_pool
Dark Pool: ALNY — 1.8M shares, 59,669 trades
Week starting 2026-05-04. Total ATS volume: 1,833,195 shares across 59,669 trades.
Apr 30, 2026
Clinical Trial
A Study to Evaluate Zilebesiran in Japanese Patients With Mild to Moderate Hypertension
Phase Phase 2 — COMPLETED
Apr 30, 2026
earnings_calendar
ALNY Q1 2026 Earnings Scheduled — 2026-04-30
Apr 30, 2026
short_volume
Short Volume: ALNY — 65.3% short (0.7M / 1.1M)
Short: 695,814 | Exempt: 3 | TRF Vol: 1,064,804 | Short Ratio: 65.3% | Off-exchange volume (dark pool + OTC)
Apr 27, 2026
dark_pool
Dark Pool: ALNY — 2.6M shares, 64,237 trades
Week starting 2026-04-27. Total ATS volume: 2,618,547 shares across 64,237 trades.
Apr 21, 2026
short_volume
Short Volume: ALNY — 67.5% short (0.4M / 0.7M)
Short: 440,849 | Exempt: 199 | TRF Vol: 652,848 | Short Ratio: 67.5% | Off-exchange volume (dark pool + OTC)
Apr 20, 2026
Clinical Trial
APOLLO-B: A Study to Evaluate Patisiran in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR Amyloidosis With Cardiomyopathy)
Phase Phase 3 — COMPLETED
Apr 20, 2026
dark_pool
Dark Pool: ALNY — 1.4M shares, 47,858 trades
Week starting 2026-04-20. Total ATS volume: 1,433,432 shares across 47,858 trades.
Apr 13, 2026
dark_pool
Dark Pool: ALNY — 1.7M shares, 51,701 trades
Week starting 2026-04-13. Total ATS volume: 1,653,699 shares across 51,701 trades.
Apr 7, 2026
short_volume
Short Volume: ALNY — 77.6% short (0.5M / 0.7M)
Short: 540,526 | Exempt: 47 | TRF Vol: 696,367 | Short Ratio: 77.6% | Off-exchange volume (dark pool + OTC)
Apr 6, 2026
dark_pool
Dark Pool: ALNY — 1.9M shares, 60,451 trades
Week starting 2026-04-06. Total ATS volume: 1,930,840 shares across 60,451 trades.
Apr 6, 2026
short_volume
Short Volume: ALNY — 63.9% short (0.3M / 0.5M)
Short: 329,515 | Exempt: 4,056 | TRF Vol: 515,803 | Short Ratio: 63.9% | Off-exchange volume (dark pool + OTC)
Mar 30, 2026
dark_pool
Dark Pool: ALNY — 1.3M shares, 40,483 trades
Week starting 2026-03-30. Total ATS volume: 1,324,948 shares across 40,483 trades.
Mar 2, 2026
Clinical Trial
Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)
Phase Phase 2 — COMPLETED