AXSM

Axsome Therapeutics, Inc.

Nasdaq · Pharmaceutical Preparations · Inc. DE · CIK 0001579428
$232.32 +0.36% $11.9B
Insider Selling Cluster (2 insiders)High Impact Filing (7/10)5 New Institutional Positions
Vol
Market Cap$11.9B
Cap SizeLarge Cap
Analyst ConsensusStrong Buy (93%)
Inst. Holders9 funds
Inst. Value$1.4B
Inst. Activity5 buys / 0 sells
Insider Activity0B / 8S
Insider Net $-$16.5M
Reddit Sentiment50° Neutral
SEC Reports6
Press Releases3
Exchange Nasdaq·Sector Pharmaceutical Preparations·Inc. DE·CIK 0001579428·Prev Close $231.48

Recent Activity

Jun 4, 2026 Press
Axsome Therapeutics announced presentations of new SYMBRAVO® data at the AHS 68th Annual Scientific Meeting, including p
Impact 3/10
Jun 4, 2026 fda
Axsome Therapeutics Presents New SYMBRAVO® Data at the Americal Headache Society (AHS) 68th Annual Scientific Meeting
<p align="justify">NEW YORK, June 04, 2026 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ:
Jun 3, 2026 SEC
Axsome settled all SUNOSI patent litigation, granting five generic companies entry rights no earlier than March 2040 (or
8-K — Impact 7/10
Jun 2, 2026 Insider
Coleman Mark sold 5,537 shares
Director @ $223.39 ($1.2M)
Jun 1, 2026 Insider
Coleman Mark sold 6,000 shares
Director @ $230.30 ($1.4M)
Jun 1, 2026 Event
AUVELITY
WARNING: SUICIDAL THOUGHTS AND BEHAVIORS Antidepressants increased the risk of suicidal thoughts and
May 29, 2026 Insider
Coleman Mark sold 6,000 shares
Director @ $233.46 ($1.4M)
May 4, 2026 SEC
Axsome reported Q1 2026 revenue of $191.2M (+57% YoY), slightly above the $190.7M consensus, but net loss widened to -$6
8-K — Impact 6/10

Price Targets

$270.28 +16.3% upside Buy
Current $232.32 Low $200.00 Median $272.00 High $328.81 21 analysts
$200.00 $328.81

Analyst Ratings

Strong Buy93% buy · 27 analysts
10Strong Buy
15Buy
2Hold
0Sell
0Strong Sell
Recent Analyst Actions
DateFirmActionRating
May 5, 2026 Morgan Stanley MAINTAIN Equal-Weight → Equal-Weight
May 5, 2026 RBC Capital MAINTAIN Outperform → Outperform
May 5, 2026 Wells Fargo MAINTAIN Overweight → Overweight
May 5, 2026 Guggenheim MAINTAIN Buy → Buy
May 5, 2026 Mizuho MAINTAIN Outperform → Outperform

Earnings Estimates

PeriodEPS Est.RangeGrowth#
Current Q $-0.82 ▼ -47.5% $-1.21 — $-0.05 16% YoY 8
Next Q $-0.34 ▼ -472.0% $-0.77 — $0.62 64% YoY 8
Current FY $-1.71 ▼ -63.7% $-3.35 — $1.30 51% YoY 8
Next FY $5.89 ▼ -3.2% $1.63 — $12.53 445% YoY 9

Top Institutional Holders

FundValueMove
VANGUARD GROUP INC$760.7M
FMR LLC$215.8MADD
BANK OF AMERICA CORP$112.9MADD
NORGES BANK$90.5MNEW
MORGAN STANLEY$89.7MADD

Recent Insider Trades

DateInsiderTypeValue
Jun 2, 2026Coleman MarkSELL$1.2M
Jun 1, 2026Coleman MarkSELL$1.4M
May 29, 2026Coleman MarkSELL$1.4M
May 5, 2026Jacobson MarkM$0.00
May 5, 2026Jacobson MarkSELL$53.2K

Reddit Sentiment

50°
Neutral
Bearish Neutral Bullish
2 mentions 0 bullish 0 bearish
9 institutional holders with $1.4B total value (7,759,088 shares) as of 2025-Q4. Top holders: VANGUARD, FMR, BANK. Net buying activity: 5 institutions added/increased vs 0 reduced.

Top Institutional Holders — 2025-Q4

#FundSharesValue% of TrackedLast Move
1VANGUARD GROUP INC4,164,818$760.7M53.7%
2FMR LLC1,181,622$215.8M15.2%ADD +27.3%
3BANK OF AMERICA CORP /DE/618,033$112.9M8.0%ADD +71.1%
4NORGES BANK495,456$90.5M6.4%NEW
5MORGAN STANLEY491,201$89.7M6.3%ADD +40.6%
6CHARLES SCHWAB INVESTMENT MANAGEMENT INC402,700$73.5M5.2%NEW
7RENAISSANCE TECHNOLOGIES LLC170,000$31.0M2.2%NEW
8TWO SIGMA INVESTMENTS, LP145,597$26.6M1.9%DOUBLED +1674.1%
9WELLS FARGO & COMPANY/MN89,661$16.4M1.2%ADD +62.2%

Recent Position Changes

FundActionPrev SharesCurr SharesChange %ValueQuarter
FMR LLCADD927,8831,181,622+27.3%$215.8M2025-Q4
BANK OF AMERICA CORP /DE/ADD361,261618,033+71.1%$112.9M2025-Q4
NORGES BANKNEW495,456$90.5M2025-Q4
TWO SIGMA INVESTMENTS, LPDOUBLED8,207145,597+1674.1%$26.6M2025-Q4
WELLS FARGO & COMPANY/MNADD55,27389,661+62.2%$16.4M2025-Q4
BANK OF AMERICA CORP /DE/TRIM753,429361,261-52.1%$43.9M2025-Q3
UBS Group AGTRIM595,455212,451-64.3%$25.8M2025-Q3
TWO SIGMA INVESTMENTS, LPNEW8,207$996.7K2025-Q3
NORGES BANKEXIT468,3290-100.0%$0.002025-Q3
BANK OF AMERICA CORP /DE/ADD533,902753,429+41.1%$78.7M2025-Q2
UBS Group AGDOUBLED288,647595,455+106.3%$62.2M2025-Q2
NORGES BANKNEW468,329$48.9M2025-Q2
WELLS FARGO & COMPANY/MNADD41,61555,703+33.9%$5.8M2025-Q2
TWO SIGMA INVESTMENTS, LPEXIT47,0050-100.0%$0.002025-Q2
UBS Group AGADD147,347288,647+95.9%$33.7M2025-Q1
CITADEL ADVISORS LLCTRIM835,089278,786-66.6%$32.5M2025-Q1
RENAISSANCE TECHNOLOGIES LLCNEW134,400$15.7M2025-Q1
TWO SIGMA INVESTMENTS, LPNEW47,005$5.5M2025-Q1
NORGES BANKEXIT403,0260-100.0%$0.002025-Q1
CITADEL ADVISORS LLCADD524,282835,089+59.3%$70.7M2024-Q4
MORGAN STANLEYADD410,150576,858+40.6%$48.8M2024-Q4
UBS Group AGDOUBLED47,762147,347+208.5%$12.5M2024-Q4
MORGAN STANLEYADD321,981410,150+27.4%$36.9M2024-Q3
CHARLES SCHWAB INVESTMENT MANAGEMENT INCNEW322,596$29.0M2024-Q3
6 unique insiders with 8 transactions. Net insider value: -$16.5M ($0.00 bought, $16.5M sold).

Insider Transactions

DateInsiderTitleTypeSharesPriceValue
Jun 2, 2026Coleman MarkDirectorSELL5,537$223.39$1.2M
Jun 1, 2026Coleman MarkDirectorSELL6,000$230.30$1.4M
May 29, 2026Coleman MarkDirectorSELL6,000$233.46$1.4M
May 5, 2026Jacobson Mark L.Chief Operating OfficerM233$0.00$0.00
May 5, 2026Jacobson Mark L.Chief Operating OfficerSELL233$228.18$53.2K
May 5, 2026Jacobson Mark L.Chief Operating OfficerM233$12.95$3.0K
May 4, 2026Jacobson Mark L.Chief Operating OfficerM4,517$0.00$0.00
May 4, 2026Jacobson Mark L.Chief Operating OfficerSELL4,517$227.94$1.0M
May 4, 2026Jacobson Mark L.Chief Operating OfficerM4,517$12.95$58.5K
Apr 22, 2026Maizel AriChief Commercial OfficerM7,500$70.73$530.5K
Apr 22, 2026Maizel AriChief Commercial OfficerSELL7,500$182.42$1.4M
Apr 22, 2026Maizel AriChief Commercial OfficerM7,500$0.00$0.00
Apr 21, 2026Murdock Hunter R.General CounselA7,224$0.00$0.00
Apr 21, 2026Pizzie NickChief Financial OfficerA8,188$0.00$0.00
Apr 21, 2026Maizel AriChief Commercial OfficerA7,224$0.00$0.00
Apr 21, 2026TABUTEAU HERRIOTChief Executive OfficerA24,081$0.00$0.00
Apr 21, 2026Jacobson Mark L.Chief Operating OfficerA8,669$0.00$0.00
Feb 26, 2026Jacobson Mark L.Chief Operating OfficerA19,663$0.00$0.00
Feb 26, 2026TABUTEAU HERRIOTChief Executive OfficerA54,623$0.00$0.00
Feb 26, 2026Maizel AriChief Commercial OfficerA16,385$0.00$0.00
Feb 26, 2026Murdock Hunter R.General CounselA16,385$0.00$0.00
Feb 26, 2026Pizzie NickChief Financial OfficerA18,570$0.00$0.00
Feb 26, 2026Jacobson Mark L.Chief Operating OfficerM35,378$2.85$100.8K
Feb 26, 2026Coleman MarkDirectorSELL25,000$161.11$4.0M
Feb 26, 2026Jacobson Mark L.Chief Operating OfficerM35,378$0.00$0.00
Feb 23, 2026Coleman MarkDirectorM6,250$4.95$30.9K
Feb 23, 2026Coleman MarkDirectorM6,250$0.00$0.00
Feb 20, 2026Coleman MarkDirectorM12,485$0.00$0.00
Feb 20, 2026Coleman MarkDirectorM12,485$4.95$61.8K
Feb 10, 2026Coleman MarkDirectorM5,193$0.00$0.00
Feb 10, 2026Coleman MarkDirectorM5,193$8.02$41.6K
Feb 2, 2026TABUTEAU HERRIOTChief Executive OfficerM32,410$8.02$259.9K
Feb 2, 2026TABUTEAU HERRIOTChief Executive OfficerSELL32,410$185.60$6.0M
Feb 2, 2026TABUTEAU HERRIOTChief Executive OfficerM32,410$0.00$0.00
Current analyst consensus: Strong Buy (93% buy). Based on 27 analysts: 10 strong buy, 15 buy, 2 hold, 0 sell, 0 strong sell.

Analyst Price Targets

$270.28 mean target +16.3% upside Buy (1.24)
$200.00 Low $328.81 High
MetricValue
Current Price$232.32
Target Low$200.00
Target Mean$270.28
Target Median$272.00
Target High$328.81
# Analysts21
RecommendationBuy (1.24)

Earnings Estimates & Revisions

PeriodEPS AvgEPS LowEPS HighEPS Growth30d Rev.Up/DownRev. AvgRev. GrowthAnalysts
Current Q
2026-06-30
$-0.82 $-1.21 $-0.05 15.7% -47.5% 1↑ 3↓ $0.2B 48.2% 8
Next Q
2026-09-30
$-0.34 $-0.77 $0.62 64.4% -472.0% 0↑ 4↓ $0.3B 53.8% 8
Current FY
2026-12-31
$-1.71 $-3.35 $1.30 50.9% -63.7% 1↑ 5↓ $1.0B 54.4% 8
Next FY
2027-12-31
$5.89 $1.63 $12.53 445.1% -3.2% 3↑ 2↓ $1.6B 61.7% 9

Current Quarter EPS Revision History

TimepointEPS EstimateChange
Current$-0.818
7d ago$-0.650-0.167
30d ago$-0.554-0.263
60d ago$-0.554-0.263
90d ago$-0.301-0.516
13 analyst firms have rated this stock: 0 upgrades, 1 downgrades, 1 initiations.

Individual Analyst Actions

DateAnalyst FirmActionPrevious RatingNew Rating
May 5, 2026 Morgan Stanley MAINTAIN Equal-Weight Equal-Weight
May 5, 2026 RBC Capital MAINTAIN Outperform Outperform
May 5, 2026 Wells Fargo MAINTAIN Overweight Overweight
May 5, 2026 Guggenheim MAINTAIN Buy Buy
May 5, 2026 Mizuho MAINTAIN Outperform Outperform
May 5, 2026 Baird MAINTAIN Outperform Outperform
May 5, 2026 HC Wainwright & Co. MAINTAIN Buy Buy
May 5, 2026 Needham MAINTAIN Buy Buy
May 4, 2026 Jefferies MAINTAIN Buy Buy
May 4, 2026 HC Wainwright & Co. MAINTAIN Buy Buy
May 1, 2026 Needham MAINTAIN Buy Buy
Apr 10, 2026 UBS MAINTAIN Buy Buy
Mar 25, 2026 Guggenheim MAINTAIN Buy Buy
Feb 24, 2026 UBS MAINTAIN Buy Buy
Feb 24, 2026 Guggenheim MAINTAIN Buy Buy
Feb 24, 2026 RBC Capital MAINTAIN Outperform Outperform
Feb 24, 2026 Wells Fargo MAINTAIN Overweight Overweight
Feb 24, 2026 Wolfe Research INITIATE Outperform
Feb 23, 2026 Needham REITERATE Buy Buy
Feb 3, 2026 Jefferies MAINTAIN Buy Buy
Jan 28, 2026 Leerink Partners MAINTAIN Outperform Outperform
Jan 21, 2026 RBC Capital MAINTAIN Outperform Outperform
Jan 20, 2026 HC Wainwright & Co. MAINTAIN Buy Buy
Jan 16, 2026 Piper Sandler MAINTAIN Overweight Overweight
Jan 13, 2026 Wells Fargo MAINTAIN Overweight Overweight
Jan 8, 2026 Morgan Stanley DOWNGRADE Overweight Equal-Weight
Jan 6, 2026 UBS MAINTAIN Buy Buy
Jan 5, 2026 HC Wainwright & Co. MAINTAIN Buy Buy
Dec 31, 2025 Needham MAINTAIN Buy Buy

Monthly Consensus History

PeriodStrong BuyBuyHoldSellStrong SellBuy %Distribution
Jun 1, 2026101520093%
May 1, 2026101520093%
Apr 1, 202691520092%
Mar 1, 202691520092%
Feb 1, 202691520092%
Jan 1, 202691610096%
Strong BuyBuyHoldSellStrong Sell

No congressional trading data available for this ticker. Data is sourced from Senate and House financial disclosure filings.

50°
Neutral
Bearish Neutral Bullish
2 mentions 0 bullish 0 bearish 2 time periods

Reddit Sentiment History

DateMentionsSentimentBullishBearishThreads
Apr 16, 2026144° Neutral001
Apr 16, 2026144° Neutral001

Recent Reddit Threads

r/wallstreetbets Neutral 1mo ago
Why is no one talking about $AXSM?
▲ 1 💬 1 ⚡ 0.5
Jun 4, 2026
fda
Axsome Therapeutics Presents New SYMBRAVO® Data at the Americal Headache Society (AHS) 68th Annual Scientific Meeting
<p align="justify">NEW YORK, June 04, 2026 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new e
Jun 1, 2026
contract
Axsome Therapeutics Partners with the Headache Alliance to Highlight the Impact of Migraine During Migraine and Headache Awareness Month
<p align="justify">NEW YORK, June 01, 2026 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new e
Jun 1, 2026
FDA
AUVELITY
WARNING: SUICIDAL THOUGHTS AND BEHAVIORS Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients i
May 29, 2026
Clinical Trial
A Study to Assess the Efficacy and Safety of AXS-12 (Reboxetine) in Patients With Narcolepsy
Phase Phase 3 — COMPLETED
May 27, 2026
other
Axsome Therapeutics to Participate in Upcoming Investor Conferences
<p align="justify">NEW YORK, May 27, 2026 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new er
May 13, 2026
short_interest
FTD: AXSM — 57,815 shares ($13.0M) failed to deliver
Settlement: 20260513, Price: $224.03, FTD Value: $12,952,294.45, AXSOME THERAPEUTICS INC COM ST
May 12, 2026
short_interest
FTD: AXSM — 39,641 shares ($8.6M) failed to deliver
Settlement: 20260512, Price: $216.47, FTD Value: $8,581,087.27, AXSOME THERAPEUTICS INC COM ST
May 11, 2026
short_interest
FTD: AXSM — 62,981 shares ($13.7M) failed to deliver
Settlement: 20260511, Price: $217.38, FTD Value: $13,690,809.78, AXSOME THERAPEUTICS INC COM ST
May 6, 2026
FDA
AUVELITY
WARNING: SUICIDAL THOUGHTS AND BEHAVIORS Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients i
May 6, 2026
FDA
AUVELITY
WARNING: SUICIDAL THOUGHTS AND BEHAVIORS Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients i
May 5, 2026
other
Axsome Therapeutics to Participate in Upcoming Investor Conferences
<p align="justify">NEW YORK, May 05, 2026 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new er
May 4, 2026
earnings
Axsome Therapeutics Reports First Quarter 2026 Financial Results and Provides Business Update
<p align="center"><em>Total 1Q 2026 net product revenue of $191.2 million, representing 57% year-over-year growth</em></p>
May 4, 2026
earnings_calendar
AXSM Q1 2026 Earnings Scheduled — 2026-05-04
May 4, 2026
short_interest
FTD: AXSM — 13,914 shares ($2.9M) failed to deliver
Settlement: 20260504, Price: $206.53, FTD Value: $2,873,658.42, AXSOME THERAPEUTICS INC COM ST
May 1, 2026
fda
Axsome Therapeutics Hosts AUVELITY® FDA Approval Investor Event Featuring Expert Thought Leader
<p align="justify">NEW YORK, May 01, 2026 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new er
Apr 30, 2026
fda
Axsome Therapeutics Announces FDA Approval of AUVELITY® (dextromethorphan HBr and bupropion HCl) for the Treatment of Agitation Associated with Dementia due to Alzheimer’s Disease
<p align="center"><em>AUVELITY is a first-in-class treatment, which targets the NMDA and sigma-1 receptors, approved for agitation associated with dem
Apr 30, 2026
fda_pdufa
PDUFA: AXSM — AXS-05 in Alzheimer's disease agitation — 2026-04-30
FDA target action date 2026-04-30 for AXSM (Axsome Therapeutics, Inc.). Drug: AXS-05. Indication: Alzheimer's disease agitation. sNDA for AXS-05 for A
Apr 30, 2026
FDA
AUVELITY
Supplemental Approval — Labeling — DEXTROMETHORPHAN HYDROBROMIDE, BUPROPION HYDROCHLORIDE — TABLET, EXTENDED RELEASE — ORAL
Apr 8, 2026
earnings
Axsome Therapeutics to Report First Quarter 2026 Financial Results on May 4
<p align="justify">NEW YORK, April 08, 2026 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new
Mar 11, 2026
short_interest
FTD: AXSM — 15,412 shares ($2.6M) failed to deliver
Settlement: 20260311, Price: $166.34, FTD Value: $2,563,632.08, AXSOME THERAPEUTICS INC COM ST