PRAX

Praxis Precision Medicines, Inc.

Nasdaq · Pharmaceutical Preparations · Inc. DE · CIK 0001689548
$257.25 -2.76% $7.2B
High Impact Filing (8/10)28 New Institutional Positions12 Institutional Exits
Vol
Market Cap$7.2B
Cap SizeMid Cap
Analyst ConsensusStrong Buy (87%)
Inst. Holders50 funds
Inst. Value$5.3B
Inst. Activity28 buys / 12 sells
Reddit Sentiment50° Neutral
SEC Reports5
Press Releases4
Exchange Nasdaq·Sector Pharmaceutical Preparations·Inc. DE·CIK 0001689548·Prev Close $264.54

Price Targets

$627.59 +144.0% upside Strong Buy
Current $257.25 Low $162.00 Median $550.00 High $1,201.00 17 analysts
$162.00 $1,201.00

Analyst Ratings

Strong Buy87% buy · 23 analysts
9Strong Buy
11Buy
2Hold
0Sell
1Strong Sell
Recent Analyst Actions
DateFirmActionRating
Jun 2, 2026 Oppenheimer MAINTAIN Outperform → Outperform
Jun 2, 2026 Truist Securities MAINTAIN Buy → Buy
Jun 2, 2026 Deutsche Bank MAINTAIN Buy → Buy
Jun 2, 2026 Wedbush MAINTAIN Underperform → Underperform
Jun 2, 2026 Baird MAINTAIN Outperform → Outperform

Earnings Estimates

PeriodEPS Est.RangeGrowth#
Current Q $-3.71 ▲ +2.3% $-5.33 — $-3.04 -12% YoY 14
Next Q $-4.05 ▼ -2.3% $-6.46 — $-3.30 -21% YoY 14
Current FY $-15.27 $-22.94 — $-13.25 -13% YoY 14
Next FY $-10.18 ▼ -18.6% $-22.60 — $3.38 33% YoY 13

Top Institutional Holders

FundValueMove
NOMURA ASSET MANAGEMENT CO
BlackRock, Inc.$749.1M
FMR LLC$696.2MADD
BAKER BROS. ADVISORS LP$564.9MADD
VANGUARD CAPITAL MANAGEMENT LLC$393.7M

Recent Insider Trades

DateInsiderTypeValue
Jun 10, 2026Cudkowicz MeritA$0.00
Jun 10, 2026Norden GregoryA$0.00
Jun 10, 2026YOUNG WILLIAMA$0.00
Jun 10, 2026Norden GregoryA$0.00
Jun 10, 2026Chodakewitz JeffreyA$0.00

Reddit Sentiment

50°
Neutral
Bearish Neutral Bullish
3 mentions 0 bullish 0 bearish
50 institutional holders with $5.3B total value (16,303,648 shares) as of 2026-Q1. Top holders: NOMURA, BlackRock,, FMR. Net buying activity: 28 institutions added/increased vs 12 reduced.

Top Institutional Holders — 2026-Q1

#FundSharesValue% of TrackedLast Move
1NOMURA ASSET MANAGEMENT CO LTD$0.000.0%
2BlackRock, Inc.2,324,929$749.1M14.3%
3FMR LLC2,160,943$696.2M13.3%ADD +59.0%
4BAKER BROS. ADVISORS LP1,753,198$564.9M10.8%ADD +55.6%
5VANGUARD CAPITAL MANAGEMENT LLC1,221,944$393.7M7.5%
6DRIEHAUS CAPITAL MANAGEMENT LLC949,225$305.8M5.8%ADD +86.4%
7STATE STREET CORP884,238$284.9M5.4%
8MORGAN STANLEY833,491$268.5M5.1%ADD +38.3%
9ADAGE CAPITAL PARTNERS GP, L.L.C.815,739$262.8M5.0%TRIM -59.3%
10VANGUARD PORTFOLIO MANAGEMENT LLC756,748$243.8M4.6%
11GOLDMAN SACHS GROUP INC710,734$229.0M4.4%
12BANK OF AMERICA CORP /DE/534,604$172.2M3.3%
13RA CAPITAL MANAGEMENT, L.P.373,787$120.4M2.3%NEW
14Hood River Capital Management LLC358,618$115.5M2.2%NEW
15Pictet Asset Management Holding SA286,644$91.4M1.7%NEW
16FRANKLIN RESOURCES INC276,123$89.0M1.7%
17CHARLES SCHWAB INVESTMENT MANAGEMENT INC215,447$69.4M1.3%
18Woodline Partners LP200,013$64.4M1.2%ADD +89.7%
19WELLINGTON MANAGEMENT GROUP LLP174,350$56.2M1.1%DOUBLED +188.3%
20VANGUARD FIDUCIARY TRUST CO169,902$54.7M1.0%

Recent Position Changes

FundActionPrev SharesCurr SharesChange %ValueQuarter
FMR LLCADD1,358,6752,160,943+59.0%$696.2M2026-Q1
BAKER BROS. ADVISORS LPADD1,126,4881,753,198+55.6%$564.9M2026-Q1
Woodline Partners LPADD105,412200,013+89.7%$64.4M2026-Q1
JANUS HENDERSON GROUP PLCNEAR_EXIT3,240,08684,947-97.4%$27.4M2026-Q1
MetLife Investment Management, LLCDOUBLED12,42480,930+551.4%$26.1M2026-Q1
Nuveen, LLCADD49,97072,043+44.2%$23.2M2026-Q1
FRONTIER CAPITAL MANAGEMENT CO LLCNEW53,365$17.2M2026-Q1
Universal- Beteiligungs- und Servicegesellschaft mbHADD37,37747,432+26.9%$15.3M2026-Q1
MARSHALL WACE, LLPTRIM69,24245,149-34.8%$14.5M2026-Q1
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEMNEW42,163$13.6M2026-Q1
CANADA PENSION PLAN INVESTMENT BOARDTRIM69,71240,130-42.4%$12.9M2026-Q1
FIRST TRUST ADVISORS LPTRIM88,70433,335-62.4%$10.7M2026-Q1
AMERIPRISE FINANCIAL INCADD22,71531,220+37.4%$10.1M2026-Q1
DIMENSIONAL FUND ADVISORS LPADD23,54331,161+32.4%$10.0M2026-Q1
PRUDENTIAL FINANCIAL INCDOUBLED14,86230,510+105.3%$9.8M2026-Q1
SEI INVESTMENTS COADD15,79629,525+86.9%$9.5M2026-Q1
VOYA INVESTMENT MANAGEMENT LLCDOUBLED13,65528,134+106.0%$9.1M2026-Q1
Rafferty Asset Management, LLCTRIM22,24015,188-31.7%$4.9M2026-Q1
Allianz Asset Management GmbHDOUBLED2,40014,030+484.6%$4.5M2026-Q1
Allspring Global Investments Holdings, LLCDOUBLED1,7328,536+392.8%$2.7M2026-Q1
MASSACHUSETTS FINANCIAL SERVICES CO /MA/DOUBLED3,3167,388+122.8%$2.4M2026-Q1
Vestmark Advisory Solutions, Inc.ADD4,5056,681+48.3%$2.2M2026-Q1
LOS ANGELES CAPITAL MANAGEMENT LLCDOUBLED5525,060+816.7%$1.6M2026-Q1
GLENMEDE TRUST CO NATRIM6,2883,410-45.8%$1.1M2026-Q1
XPONANCE LLCADD1,7642,420+37.2%$779.7K2026-Q1
13 unique insiders with 25 transactions. Net insider value: $0.00 ($0.00 bought, $0.00 sold).

Insider Transactions

DateInsiderTitleTypeSharesPriceValue
Jun 10, 2026Cudkowicz Merit EsterDirectorAWARD648
Jun 10, 2026Norden GregoryDirectorAWARD1,371
Jun 10, 2026YOUNG WILLIAM DDirectorAWARD648
Jun 10, 2026Norden GregoryDirectorAWARD648
Jun 10, 2026Chodakewitz JeffreyDirectorAWARD1,371
Jun 10, 2026KINDLER JEFFREY BDirectorAWARD1,371
Jun 10, 2026YOUNG WILLIAM DDirectorAWARD1,371
Jun 10, 2026KINDLER JEFFREY BDirectorAWARD648
Jun 10, 2026MITCHELL DEAN JDirectorAWARD1,371
Jun 10, 2026MITCHELL DEAN JDirectorAWARD648
Jun 10, 2026Cudkowicz Merit EsterDirectorAWARD1,371
Jun 10, 2026Chodakewitz JeffreyDirectorAWARD648
Jun 10, 2026DeSimone JillDirectorAWARD1,371
Jun 10, 2026DeSimone JillDirectorAWARD648
Jun 10, 2026Arbuckle Stuart ADirectorAWARD1,371
Jun 10, 2026Arbuckle Stuart ADirectorAWARD648
May 14, 2026Souza MarcioChief Executive OfficerAWARD126$167.94$21.2K
May 14, 2026Sniecinski MeganChief Operating OfficerAWARD89$167.94$14.9K
May 14, 2026Kelly Timothy EdwinChief Financial OfficerAWARD121$167.94$20.3K
May 14, 2026Nemiroff AlexGeneral Counsel and SecretaryAWARD78$167.94$13.1K
May 14, 2026Mastrocola LaurenPrincipal Accounting OfficerAWARD127$167.94$21.3K
Feb 6, 2026KINDLER JEFFREY BDirectorAWARD224
Feb 6, 2026KINDLER JEFFREY BDirectorAWARD688
Feb 6, 2026Arbuckle Stuart ADirectorAWARD224
Feb 6, 2026Arbuckle Stuart ADirectorAWARD688
Current analyst consensus: Strong Buy (87% buy). Based on 23 analysts: 9 strong buy, 11 buy, 2 hold, 0 sell, 1 strong sell.

Analyst Price Targets

$627.59 mean target +144.0% upside Strong Buy (1.47)
$162.00 Low $1,201.00 High
MetricValue
Current Price$257.25
Target Low$162.00
Target Mean$627.59
Target Median$550.00
Target High$1,201.00
# Analysts17
RecommendationStrong Buy (1.47)

Earnings Estimates & Revisions

PeriodEPS AvgEPS LowEPS HighEPS Growth30d Rev.Up/DownRev. AvgRev. GrowthAnalysts
Current Q
2026-06-30
$-3.71 $-5.33 $-3.04 -12.1% +2.3% 4↑ 8↓ $0.0B 0.0% 14
Next Q
2026-09-30
$-4.05 $-6.46 $-3.30 -20.6% -2.3% 4↑ 8↓ $0.0B 0.0% 14
Current FY
2026-12-31
$-15.27 $-22.94 $-13.25 -13.3% -0.3% 6↑ 8↓ $0.0B 0.0% 14
Next FY
2027-12-31
$-10.18 $-22.60 $3.38 33.3% -18.6% 5↑ 5↓ $0.3B 7402.2% 13

Current Quarter EPS Revision History

TimepointEPS EstimateChange
Current$-3.711
7d ago$-3.694-0.017
30d ago$-3.797+0.086
60d ago$-3.794+0.083
90d ago$-3.794+0.083
12 analyst firms have rated this stock: 0 upgrades, 0 downgrades, 2 initiations.

Individual Analyst Actions

DateAnalyst FirmActionPrevious RatingNew Rating
Jun 2, 2026 Oppenheimer MAINTAIN Outperform Outperform
Jun 2, 2026 Truist Securities MAINTAIN Buy Buy
Jun 2, 2026 Deutsche Bank MAINTAIN Buy Buy
Jun 2, 2026 Wedbush MAINTAIN Underperform Underperform
Jun 2, 2026 Baird MAINTAIN Outperform Outperform
Jun 2, 2026 HC Wainwright & Co. MAINTAIN Buy Buy
Jun 2, 2026 BTIG MAINTAIN Buy Buy
May 26, 2026 HC Wainwright & Co. REITERATE Buy Buy
May 20, 2026 BTIG REITERATE Buy Buy
May 13, 2026 Truist Securities MAINTAIN Buy Buy
May 8, 2026 Wedbush MAINTAIN Underperform Underperform
May 8, 2026 BTIG REITERATE Buy Buy
Apr 14, 2026 Needham REITERATE Buy Buy
Apr 7, 2026 HC Wainwright & Co. REITERATE Buy Buy
Apr 6, 2026 BTIG REITERATE Buy Buy
Feb 24, 2026 Wolfe Research INITIATE Outperform
Feb 20, 2026 Wells Fargo MAINTAIN Equal-Weight Equal-Weight
Feb 20, 2026 Baird MAINTAIN Outperform Outperform
Feb 20, 2026 Truist Securities MAINTAIN Buy Buy
Feb 20, 2026 Wedbush MAINTAIN Underperform Underperform
Feb 10, 2026 Guggenheim MAINTAIN Buy Buy
Feb 4, 2026 Needham MAINTAIN Buy Buy
Feb 2, 2026 Wells Fargo INITIATE Equal-Weight
Jan 30, 2026 HC Wainwright & Co. MAINTAIN Buy Buy
Jan 28, 2026 Piper Sandler MAINTAIN Overweight Overweight
Jan 12, 2026 Wedbush MAINTAIN Underperform Underperform
Dec 29, 2025 BTIG MAINTAIN Buy Buy

Monthly Consensus History

PeriodStrong BuyBuyHoldSellStrong SellBuy %Distribution
Jun 1, 202691120187%
May 1, 202691120187%
Apr 1, 202681120186%
Mar 1, 202681220187%
Feb 1, 202671210190%
Jan 1, 202671210190%
Strong BuyBuyHoldSellStrong Sell

No congressional trading data available for this ticker. Data is sourced from Senate and House financial disclosure filings.

50°
Neutral
Bearish Neutral Bullish
3 mentions 0 bullish 0 bearish 3 time periods

Reddit Sentiment History

DateMentionsSentimentBullishBearishThreads
Mar 31, 2026150° Neutral001
Mar 31, 2026150° Neutral001
Feb 25, 2026156° Neutral001
Jan 29, 2027
fda_pdufa
PDUFA: PRAX — ulixacaltamide in Essential Tremor — 2027-01-29
FDA target action date 2027-01-29 for PRAX (Praxis Precision Medicines, Inc.). Drug: ulixacaltamide. Indication: Essential Tremor. FDA accepted NDA fo
Sep 27, 2026
fda_pdufa
PDUFA: PRAX — relutrigine in SCN2A and SCN8A developmental and epileptic encephalopathies — 2026-09-27
FDA target action date 2026-09-27 for PRAX (Praxis Precision Medicines, Inc.). Drug: relutrigine. Indication: SCN2A and SCN8A developmental and epilep
Jun 4, 2026
other
Praxis Precision Medicines to Participate in Goldmans Sachs 47th Annual Global Healthcare Conference
<p align="left">BOSTON, June 04, 2026 (GLOBE NEWSWIRE) -- <a href="https://www.globenewswire.com/Tracker?data=_kcvXLmzZYfJ_cQTmaNQWB8pKLq2RGx7j3CKuK
Jun 2, 2026
activist
Praxis Precision Medicines, Inc. Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)
<p align="left">BOSTON, June 02, 2026 (GLOBE NEWSWIRE) -- Praxis Precision Medicines, Inc. (Nasdaq: PRAX), a fully integrated, leading central nervo
Jun 1, 2026
other
Praxis Precision Medicines Provides Vormatrigine Program Update
<p align="center"><em>POWER1 Study in highly refractory patients with focal onset seizures did not meet its primary success measure</em></p>
May 18, 2026
ftd
FTD: PRAX — 2,579 shares ($0.9M) failed to deliver
Settlement: 20260518, Price: $342.58, FTD Value: $883,513.82, PRAXIS PRECISION MEDICINES INC
May 13, 2026
earnings_calendar
PRAX Q1 2026 Earnings Scheduled — 2026-05-13
May 7, 2026
earnings
Praxis Precision Medicines Provides Corporate Update and Reports First Quarter 2026 Financial Results
<p align="center"><em>FDA accepted the new drug application (NDA) for ulixacaltamide in Essential Tremor with a PDUFA target action date of January 29
May 7, 2026
earnings_calendar
PRAX Q1 2026 Earnings Scheduled — 2026-05-07
May 5, 2026
other
Praxis Precision Medicines, Inc. Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)
<p align="left">BOSTON, May 05, 2026 (GLOBE NEWSWIRE) -- Praxis Precision Medicines, Inc. (Nasdaq: PRAX), a fully integrated, leading central nervou
May 4, 2026
earnings
Praxis Precision Medicines to Report First Quarter 2026 Financial Results on Thursday, May 7, 2026, and Participate in Upcoming Investor Conference
<p align="left">BOSTON, May 04, 2026 (GLOBE NEWSWIRE) -- Praxis Precision Medicines, Inc. (NASDAQ: PRAX), a fully integrated, leading central nervou
Apr 30, 2026
earnings_calendar
PRAX Q1 2026 Earnings Scheduled — 2026-04-30
Apr 14, 2026
fda
Praxis Precision Medicines Announces FDA Acceptance of New Drug Application for Ulixacaltamide HCl in Patients with Essential Tremor
<p align="center"><em>FDA assigned PDUFA target action date of January 29, 2027</em></p>
Apr 6, 2026
fda
Praxis Precision Medicines Announces Positive Results from the EMBRAVE Part A Trial of Elsunersen in Patients with SCN2A Early-Onset Developmental and Epileptic Encephalopathy
<p align="center"><em>Elsunersen demonstrated placebo-adjusted seizure reduction from baseline of 77% (p=0.015)</em></p>
Apr 2, 2026
other
Praxis Precision Medicines, Inc. Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)
<p align="left">BOSTON, April 02, 2026 (GLOBE NEWSWIRE) -- Praxis Precision Medicines, Inc. (Nasdaq: PRAX), a fully integrated, leading central nerv