PTCT

PTC THERAPEUTICS, INC.

Nasdaq · Pharmaceutical Preparations · Inc. DE · CIK 0001070081
$75.14 +0.58% $6.2B
Insider Selling Cluster (2 insiders)27 New Institutional Positions13 Institutional Exits
Vol
Market Cap$6.2B
Cap SizeMid Cap
Analyst ConsensusStrong Buy (76%)
Inst. Holders50 funds
Inst. Value$4.9B
Inst. Activity27 buys / 13 sells
Insider Activity0B / 21S
Insider Net $-$6.7M
SEC Reports8
Exchange Nasdaq·Sector Pharmaceutical Preparations·Inc. DE·CIK 0001070081·Prev Close $74.71

Recent Activity

Jun 11, 2026 short_volume
Short Volume: PTCT — 86.6% short (1.0M / 1.2M)
Short: 998,323 | Exempt: 0 | TRF Vol: 1,153,298 | Short Ratio: 86.6% | Off-exchange volume (dark poo
Jun 10, 2026 Insider
Pauwels Eric sold 3,711 shares
CHIEF BUSINESS OFFICER @ $75.00 ($278.3K)
Jun 10, 2026 Insider
Pauwels Eric acquired via exercise 17,566 shares
CHIEF BUSINESS OFFICER @ $18.01 ($316.4K)
Jun 10, 2026 Insider
Pauwels Eric sold 17,566 shares
CHIEF BUSINESS OFFICER
Jun 9, 2026 SEC
Board member Alethia Young resigned effective June 8, 2026, citing a need to focus on other work commitments, with no di
8-K — Impact 2/10
May 19, 2026 SEC
Two insiders at PTC Therapeutics sold a combined $220K of stock shortly after a strong Q1 earnings beat and raised guida
CLUSTER — Impact 2/10
May 15, 2026 SEC
Two PTCT insiders, including CEO Matthew Klein, sold a combined ~$115K in open-market sales within a week of the company
CLUSTER — Impact 2/10
Inst.
JANUS HENDERSON GROUP PLC — ADD
7,193,433 shares ($490.0M)

Price Targets

$93.93 +25.0% upside Strong Buy
Current $75.14 Low $65.00 Median $92.50 High $124.00 14 analysts
$65.00 $124.00

Analyst Ratings

Buy76% buy · 21 analysts
5Strong Buy
11Buy
4Hold
1Sell
0Strong Sell
Recent Analyst Actions
DateFirmActionRating
May 27, 2026 Jefferies UPGRADE Hold → Buy
May 8, 2026 TD Cowen UPGRADE Hold → Buy
May 8, 2026 RBC Capital MAINTAIN Sector Perform → Sector Perform
May 8, 2026 Wells Fargo MAINTAIN Overweight → Overweight
Mar 30, 2026 Jefferies DOWNGRADE Buy → Hold

Earnings Estimates

PeriodEPS Est.RangeGrowth#
Current Q $0.33 ▲ +172.5% $0.28 — $0.43 140% YoY 3
Next Q $0.47 ▲ +191.0% $0.29 — $0.58 152% YoY 3
Current FY $1.31 ▲ +166.7% $0.85 — $1.71 -83% YoY 3
Next FY $2.78 ▲ +14.5% $1.29 — $4.18 112% YoY 3

Top Institutional Holders

FundValueMove
NOMURA ASSET MANAGEMENT CO
BlackRock, Inc.$882.2MADD
RTW INVESTMENTS, LP$527.8M
JANUS HENDERSON GROUP PLC$490.0MADD
VANGUARD PORTFOLIO MANAGEMENT LLC$327.3M

Recent Insider Trades

DateInsiderTypeValue
Jun 10, 2026Pauwels EricSELL$278.3K
Jun 10, 2026Pauwels EricM$316.4K
Jun 10, 2026Pauwels EricSELL$0.00
May 15, 2026Boulding MarkM$72.2K
May 15, 2026Boulding MarkSELL$169.8K
50 institutional holders with $4.9B total value (71,972,716 shares) as of 2026-Q1. Top holders: NOMURA, BlackRock,, RTW. Net buying activity: 27 institutions added/increased vs 13 reduced.

Top Institutional Holders — 2026-Q1

#FundSharesValue% of TrackedLast Move
1NOMURA ASSET MANAGEMENT CO LTD$0.000.0%
2BlackRock, Inc.12,948,717$882.2M18.0%ADD +79.2%
3RTW INVESTMENTS, LP7,746,415$527.8M10.8%
4JANUS HENDERSON GROUP PLC7,193,433$490.0M10.0%ADD +48.3%
5VANGUARD PORTFOLIO MANAGEMENT LLC4,804,594$327.3M6.7%
6STATE STREET CORP4,346,519$296.1M6.0%ADD +34.2%
7WELLINGTON MANAGEMENT GROUP LLP3,942,610$268.6M5.5%
8VANGUARD CAPITAL MANAGEMENT LLC3,676,256$250.5M5.1%
9TORONTO DOMINION BANK3,025,963$206.2M4.2%TRIM -26.9%
10BANK OF AMERICA CORP /DE/1,886,841$128.6M2.6%ADD +31.8%
11Hood River Capital Management LLC1,664,559$113.4M2.3%ADD +65.9%
12D. E. Shaw & Co., Inc.1,640,381$111.8M2.3%
13FMR LLC1,528,362$104.1M2.1%
14Pictet Asset Management Holding SA1,183,720$80.1M1.6%TRIM -30.5%
15FRANKLIN RESOURCES INC1,121,388$76.4M1.6%
16DRIEHAUS CAPITAL MANAGEMENT LLC1,015,772$69.2M1.4%
17DIMENSIONAL FUND ADVISORS LP890,715$60.7M1.2%ADD +42.0%
18Invesco Ltd.865,451$59.0M1.2%ADD +99.3%
19GOLDMAN SACHS GROUP INC827,631$56.4M1.1%
20Woodline Partners LP744,988$50.8M1.0%ADD +30.3%

Recent Position Changes

FundActionPrev SharesCurr SharesChange %ValueQuarter
JANUS HENDERSON GROUP PLCADD4,851,3327,193,433+48.3%$490.0M2026-Q1
TORONTO DOMINION BANKTRIM4,138,2153,025,963-26.9%$206.2M2026-Q1
BANK OF AMERICA CORP /DE/ADD1,431,5571,886,841+31.8%$128.6M2026-Q1
Hood River Capital Management LLCADD1,003,0751,664,559+65.9%$113.4M2026-Q1
DIMENSIONAL FUND ADVISORS LPADD627,092890,715+42.0%$60.7M2026-Q1
Invesco Ltd.ADD434,285865,451+99.3%$59.0M2026-Q1
Woodline Partners LPADD571,553744,988+30.3%$50.8M2026-Q1
JUPITER ASSET MANAGEMENT LTDADD361,159711,457+97.0%$48.5M2026-Q1
MORGAN STANLEYTRIM905,192674,134-25.5%$45.9M2026-Q1
LOOMIS SAYLES & CO L PNEW493,603$33.6M2026-Q1
MARSHALL WACE, LLPADD247,746460,638+85.9%$31.4M2026-Q1
BALYASNY ASSET MANAGEMENT L.P.NEW460,564$31.4M2026-Q1
MACKENZIE FINANCIAL CORPADD236,909345,683+45.9%$23.6M2026-Q1
BNP Paribas Asset Management Holding S.A.TRIM647,585311,810-51.9%$21.2M2026-Q1
HSBC HOLDINGS PLCDOUBLED12,128227,059+1772.2%$15.5M2026-Q1
FEDERATED HERMES, INC.DOUBLED112,566225,916+100.7%$15.4M2026-Q1
SEI INVESTMENTS COADD92,089130,204+41.4%$8.9M2026-Q1
SCHRODER INVESTMENT MANAGEMENT GROUPADD72,597134,968+85.9%$8.9M2026-Q1
ARROWSTREET CAPITAL, LIMITED PARTNERSHIPTRIM406,410111,632-72.5%$7.6M2026-Q1
LOS ANGELES CAPITAL MANAGEMENT LLCDOUBLED32,42171,660+121.0%$4.9M2026-Q1
STATE OF WISCONSIN INVESTMENT BOARDADD46,77568,988+47.5%$4.7M2026-Q1
PICTON MAHONEY ASSET MANAGEMENTDOUBLED2,28053,328+2238.9%$3.6M2026-Q1
CANADA PENSION PLAN INVESTMENT BOARDTRIM75,40050,506-33.0%$3.4M2026-Q1
Allspring Global Investments Holdings, LLCDOUBLED12,18547,871+292.9%$3.3M2026-Q1
TUDOR INVESTMENT CORP ET ALDOUBLED7,41242,172+469.0%$2.9M2026-Q1
9 unique insiders with 30 transactions. Net insider value: -$6.7M ($0.00 bought, $6.7M sold).

Insider Transactions

DateInsiderTitleTypeSharesPriceValue
Jun 10, 2026Pauwels EricCHIEF BUSINESS OFFICERSELL3,711$75.00$278.3K
Jun 10, 2026Pauwels EricCHIEF BUSINESS OFFICEREXERCISE17,566$18.01$316.4K
Jun 10, 2026Pauwels EricCHIEF BUSINESS OFFICERSELL17,566
May 15, 2026Boulding Mark ElliottEXEC. VP AND CLOEXERCISE2,812$25.69$72.2K
May 15, 2026Boulding Mark ElliottEXEC. VP AND CLOSELL2,356$72.08$169.8K
May 14, 2026Klein Matthew B.CHIEF EXECUTIVE OFFICERSELL679$73.06$49.6K
May 13, 2026Klein Matthew B.CHIEF EXECUTIVE OFFICERAWARD12,500
May 8, 2026Boulding Mark ElliottEXEC. VP AND CLOEXERCISE2,740$46.54$127.5K
May 8, 2026Boulding Mark ElliottEXEC. VP AND CLOSELL840$78.23$65.7K
Apr 21, 2026Klein Matthew B.CHIEF EXECUTIVE OFFICERSELL2,850$70.91$202.1K
Apr 6, 2026Boulding Mark ElliottEXEC. VP AND CLOSELL822$68.91$56.6K
Apr 6, 2026Boulding Mark ElliottEXEC. VP AND CLOEXERCISE2,265$39.42$89.3K
Apr 2, 2026Golden Lee ScottEVP & CHIEF MEDICAL OFFICERSELL829$67.99$56.4K
Apr 1, 2026Almstead Neil GregoryCHIEF TECHNICAL OPS OFFICERSELL39,393$68.89$2.7M
Mar 24, 2026Chutter Jessica CarolineDirectorAWARD4,000
Mar 24, 2026Chutter Jessica CarolineDirectorAWARD3,475
Mar 12, 2026Klein Matthew B.CHIEF EXECUTIVE OFFICERSELL2,662$64.08$170.6K
Mar 11, 2026Klein Matthew B.CHIEF EXECUTIVE OFFICERAWARD12,500
Mar 10, 2026Okey StephanieDirectorEXERCISE1,167$33.63$39.2K
Mar 10, 2026Okey StephanieDirectorSELL1,167$70.00$81.7K
Mar 5, 2026Almstead Neil GregoryCHIEF TECHNICAL OPS OFFICERSELL3,989$63.38$252.8K
Mar 5, 2026Okey StephanieDirectorSELL6,333$63.38$401.4K
Mar 5, 2026Golden Lee ScottEVP & CHIEF MEDICAL OFFICERSELL10,000$63.38$633.8K
Feb 19, 2026Boulding Mark ElliottEXEC. VP AND CLOSELL588$68.54$40.3K
Feb 18, 2026Utter Christine MarieSVP, CHIEF ACCOUNTING OFFICERSELL2,494$69.36$173.0K
Feb 18, 2026Gravier PierreCHIEF FINANCIAL OFFICERSELL2,992$69.36$207.5K
Feb 18, 2026Pauwels EricCHIEF BUSINESS OFFICERSELL3,019$69.36$209.4K
Feb 18, 2026Klein Matthew B.CHIEF EXECUTIVE OFFICERSELL7,371$69.36$511.3K
Feb 18, 2026Golden Lee ScottEVP & CHIEF MEDICAL OFFICERSELL2,484$69.36$172.3K
Feb 18, 2026Almstead Neil GregoryCHIEF TECHNICAL OPS OFFICERSELL3,056$69.36$212.0K

No press releases analyzed yet. Press releases are collected from GlobeNewsWire and analyzed by the LLM pipeline.

Current analyst consensus: Buy (76% buy). Based on 21 analysts: 5 strong buy, 11 buy, 4 hold, 1 sell, 0 strong sell.

Analyst Price Targets

$93.93 mean target +25.0% upside Strong Buy (1.86)
$65.00 Low $124.00 High
MetricValue
Current Price$75.14
Target Low$65.00
Target Mean$93.93
Target Median$92.50
Target High$124.00
# Analysts14
RecommendationStrong Buy (1.86)

Earnings Estimates & Revisions

PeriodEPS AvgEPS LowEPS HighEPS Growth30d Rev.Up/DownRev. AvgRev. GrowthAnalysts
Current Q
2026-06-30
$0.33 $0.28 $0.43 140.2% +172.5% $0.3B 63.0% 3
Next Q
2026-09-30
$0.47 $0.29 $0.58 151.9% +191.0% $0.3B 39.3% 3
Current FY
2026-12-31
$1.31 $0.85 $1.71 -82.8% +166.7% 1↑ 0↓ $1.2B -32.2% 3
Next FY
2027-12-31
$2.78 $1.29 $4.18 111.9% +14.5% 1↑ 0↓ $1.3B 11.9% 3

Current Quarter EPS Revision History

TimepointEPS EstimateChange
Current$0.333
7d ago$0.333
30d ago$-0.460+0.793
60d ago$-0.460+0.793
90d ago$-0.460+0.793
7 analyst firms have rated this stock: 3 upgrades, 1 downgrades, 0 initiations.

Individual Analyst Actions

DateAnalyst FirmActionPrevious RatingNew Rating
May 27, 2026 Jefferies UPGRADE Hold Buy
May 8, 2026 TD Cowen UPGRADE Hold Buy
May 8, 2026 RBC Capital MAINTAIN Sector Perform Sector Perform
May 8, 2026 Wells Fargo MAINTAIN Overweight Overweight
Mar 30, 2026 Jefferies DOWNGRADE Buy Hold
Feb 23, 2026 Morgan Stanley MAINTAIN Overweight Overweight
Feb 20, 2026 Wells Fargo MAINTAIN Overweight Overweight
Feb 20, 2026 RBC Capital MAINTAIN Sector Perform Sector Perform
Feb 20, 2026 B of A Securities MAINTAIN Buy Buy
Jan 28, 2026 Barclays UPGRADE Equal-Weight Overweight

Monthly Consensus History

PeriodStrong BuyBuyHoldSellStrong SellBuy %Distribution
Jun 1, 202651141076%
May 1, 202641161068%
Apr 1, 202641061067%
Mar 1, 202661051073%
Feb 1, 202661051073%
Jan 1, 20266961068%
Strong BuyBuyHoldSellStrong Sell

No congressional trading data available for this ticker. Data is sourced from Senate and House financial disclosure filings.

No Reddit sentiment data available yet. Sentiment is analyzed from Reddit investment communities on a rolling basis.

Jun 11, 2026
short_volume
Short Volume: PTCT — 86.6% short (1.0M / 1.2M)
Short: 998,323 | Exempt: 0 | TRF Vol: 1,153,298 | Short Ratio: 86.6% | Off-exchange volume (dark pool + OTC)
Jun 9, 2026
short_volume
Short Volume: PTCT — 82.9% short (0.6M / 0.7M)
Short: 612,471 | Exempt: 0 | TRF Vol: 738,542 | Short Ratio: 82.9% | Off-exchange volume (dark pool + OTC)
Jun 8, 2026
short_volume
Short Volume: PTCT — 83.5% short (0.4M / 0.5M)
Short: 434,221 | Exempt: 800 | TRF Vol: 519,919 | Short Ratio: 83.5% | Off-exchange volume (dark pool + OTC)
May 27, 2026
short_volume
Short Volume: PTCT — 65.9% short (0.4M / 0.6M)
Short: 405,996 | Exempt: 0 | TRF Vol: 616,493 | Short Ratio: 65.9% | Off-exchange volume (dark pool + OTC)
May 12, 2026
short_volume
Short Volume: PTCT — 70.4% short (0.5M / 0.7M)
Short: 488,874 | Exempt: 5,846 | TRF Vol: 694,608 | Short Ratio: 70.4% | Off-exchange volume (dark pool + OTC)
May 11, 2026
short_volume
Short Volume: PTCT — 82.6% short (1.4M / 1.7M)
Short: 1,389,742 | Exempt: 0 | TRF Vol: 1,683,112 | Short Ratio: 82.6% | Off-exchange volume (dark pool + OTC)
May 8, 2026
short_interest
FTD: PTCT — 11,393 shares ($0.7M) failed to deliver
Settlement: 20260508, Price: $64.49, FTD Value: $734,734.57, PTC THERAPEUTICS INC COM STK (
May 7, 2026
earnings_calendar
PTCT Q1 2026 Earnings After Market Close — 2026-05-07
May 1, 2026
Clinical Trial
Study of Ataluren in Previously Treated Participants With Nonsense Mutation Dystrophinopathy (nmDBMD)
Phase Phase 3 — COMPLETED
May 1, 2026
clinical_trial_readout
Results Pending: Ataluren (Phase 3) — Completed 80d ago
Trial: Study of Ataluren in Previously Treated Participants With Nonsense Mutation Dystrophinopathy (nmDBMD) Sponsor: PTC Therapeutics Phase: Phase 3
Apr 29, 2026
short_volume
Short Volume: PTCT — 87.5% short (2.5M / 2.9M)
Short: 2,496,540 | Exempt: 1,155 | TRF Vol: 2,852,277 | Short Ratio: 87.5% | Off-exchange volume (dark pool + OTC)
Apr 28, 2026
short_volume
Short Volume: PTCT — 80.1% short (0.7M / 0.9M)
Short: 710,331 | Exempt: 0 | TRF Vol: 886,293 | Short Ratio: 80.1% | Off-exchange volume (dark pool + OTC)
Apr 23, 2026
earnings_calendar
PTCT Q1 2026 Earnings After Market Close — 2026-04-23
Apr 13, 2026
Clinical Trial
A Long-Term Safety Study of PTC923 in Participants With Phenylketonuria
Phase Phase 3 — ACTIVE_NOT_RECRUITING
Apr 13, 2026
clinical_trial_readout
T-90d Trial Readout: PTC923 (Phase 3)
Trial: A Long-Term Safety Study of PTC923 in Participants With Phenylketonuria Sponsor: PTC Therapeutics Phase: Phase 3 | Status: ACTIVE_NOT_RECRUITIN
Apr 9, 2026
short_interest
FTD: PTCT — 48,960 shares ($3.5M) failed to deliver
Settlement: 20260409, Price: $71.26, FTD Value: $3,488,889.6, PTC THERAPEUTICS INC COM STK (
Apr 8, 2026
Clinical Trial
A Study to Assess the Efficacy and Safety of Vatiquinone for the Treatment of Participants With Friedreich Ataxia
Phase Phase 3 — COMPLETED
Apr 6, 2026
clinical_trial_readout
T-90d Trial Readout: PTC923 (Phase 3)
Trial: A Long-Term Safety Study of PTC923 in Participants With Phenylketonuria Sponsor: PTC Therapeutics Phase: Phase 3 | Status: ACTIVE_NOT_RECRUITIN
Apr 1, 2026
Clinical Trial
A Study to Evaluate Efficacy and Safety of Vatiquinone for Treating Mitochondrial Disease in Participants With Refractory Epilepsy
Phase Phase 3 — TERMINATED