VRTX

VERTEX PHARMACEUTICALS INC / MA

Nasdaq · Pharmaceutical Preparations · Inc. MA · CIK 0000875320
$442.96 -0.87% $113.1B
Insider Selling Cluster (2 insiders)Congressional Activity (1)
Vol
Market Cap$113.1B
Cap SizeLarge Cap
Analyst ConsensusStrong Buy (83%)
Inst. Holders10 funds
Inst. Value$17.6B
Inst. Activity2 buys / 2 sells
Insider Activity0B / 23S
Insider Net $-$16.7M
SEC Reports10
Congressional1 trades
Exchange Nasdaq·Sector Pharmaceutical Preparations·Inc. MA·CIK 0000875320·Prev Close $446.83

Recent Activity

Price Targets

$548.69 +23.1% upside Strong Buy
Current $445.77 Low $330.00 Median $555.00 High $641.00 29 analysts
$330.00 $641.00

Analyst Ratings

Strong Buy83% buy · 40 analysts
13Strong Buy
20Buy
6Hold
0Sell
1Strong Sell
Recent Analyst Actions
DateFirmActionRating
May 6, 2026 Barclays MAINTAIN Overweight → Overweight
May 5, 2026 Canaccord Genuity MAINTAIN Hold → Hold
May 5, 2026 Morgan Stanley MAINTAIN Overweight → Overweight
May 5, 2026 Bernstein MAINTAIN Outperform → Outperform
May 5, 2026 RBC Capital MAINTAIN Outperform → Outperform

Earnings Estimates

PeriodEPS Est.RangeGrowth#
Current Q $4.73 $4.26 — $5.16 5% YoY 24
Next Q $4.95 $4.69 — $5.60 3% YoY 23
Current FY $19.15 $18.42 — $20.73 4% YoY 28
Next FY $21.47 $18.77 — $24.64 12% YoY 27

Top Institutional Holders

FundValueMove
VANGUARD GROUP INC$10.9B
NORGES BANK$1.4BNEW
MORGAN STANLEY$1.4B
BANK OF AMERICA CORP$1.3B
FMR LLC$1.0BTRIM

Recent Insider Trades

DateInsiderTypeValue
Jun 5, 2026Bozic CarmenSELL$785.3K
Jun 1, 2026Liu JoySELL$364.2K
May 29, 2026Bozic CarmenSELL$888.3K
May 15, 2026Bozic CarmenSELL$614.0K
May 15, 2026Bunnage MarkSELL$15.0K

Congressional Trades

1 members: 1 buys, 0 sells
MemberPartyTypeAmount
Ro KhannaDBUY$1,001 - $15,000
10 institutional holders with $17.6B total value (38,715,357 shares) as of 2025-Q4. Top holders: VANGUARD, NORGES, MORGAN.

Top Institutional Holders — 2025-Q4

#FundSharesValue% of TrackedLast Move
1VANGUARD GROUP INC24,105,823$10.9B62.3%
2NORGES BANK3,176,613$1.4B8.2%NEW
3MORGAN STANLEY3,120,310$1.4B8.1%
4BANK OF AMERICA CORP /DE/2,937,030$1.3B7.6%
5FMR LLC2,212,596$1.0B5.7%TRIM -33.0%
6CHARLES SCHWAB INVESTMENT MANAGEMENT INC1,859,221$842.9M4.8%NEW
7WELLS FARGO & COMPANY/MN755,413$342.5M2.0%
8RENAISSANCE TECHNOLOGIES LLC505,048$229.0M1.3%TRIM -31.4%
9Tweedy, Browne Co LLC39,148$17.7M0.1%
10TWO SIGMA INVESTMENTS, LP4,155$1.9M0.0%NEW

Recent Position Changes

FundActionPrev SharesCurr SharesChange %ValueQuarter
NORGES BANKNEW3,176,613$1.4B2025-Q4
FMR LLCTRIM3,303,7682,212,596-33.0%$1.0B2025-Q4
RENAISSANCE TECHNOLOGIES LLCTRIM735,888505,048-31.4%$229.0M2025-Q4
TWO SIGMA INVESTMENTS, LPNEW4,155$1.9M2025-Q4
FMR LLCTRIM6,406,3723,303,768-48.4%$1.3B2025-Q3
RENAISSANCE TECHNOLOGIES LLCTRIM1,004,888735,888-26.8%$288.2M2025-Q3
NORGES BANKEXIT3,580,3560-100.0%$0.002025-Q3
NORGES BANKNEW3,580,356$1.6B2025-Q2
TWO SIGMA INVESTMENTS, LPEXIT4,1210-100.0%$0.002025-Q2
CITADEL ADVISORS LLCTRIM681,081386,419-43.3%$187.3M2025-Q1
TWO SIGMA INVESTMENTS, LPNEAR_EXIT33,1604,121-87.6%$2.0M2025-Q1
NORGES BANKEXIT3,414,3240-100.0%$0.002025-Q1
CITADEL ADVISORS LLCADD353,932681,081+92.4%$274.3M2024-Q4
CHARLES SCHWAB INVESTMENT MANAGEMENT INCNEW1,626,347$756.4M2024-Q3
20 unique insiders with 23 transactions. Net insider value: -$16.7M ($0.00 bought, $16.7M sold).

Insider Transactions

DateInsiderTitleTypeSharesPriceValue
Jun 5, 2026Bozic CarmenEVP and CMOSELL1,745$450.00$785.3K
Jun 1, 2026Liu JoyEVP and Chief Legal OfficerSELL828$439.91$364.2K
May 29, 2026Bozic CarmenEVP and CMOSELL1,974$450.00$888.3K
May 15, 2026Bozic CarmenEVP and CMOSELL1,354$453.45$614.0K
May 15, 2026Bunnage Mark E.EVP, Chief Scientific OfficerSELL33$453.45$15.0K
May 12, 2026Bozic CarmenEVP and CMOSELL6,988$450.00$3.1M
May 4, 2026Bhatia Sangeeta N.DirectorSELL318$423.73$134.7K
May 1, 2026MCKENZIE DIANADirectorA796$0.00$0.00
May 1, 2026MCKENZIE DIANADirectorA943$0.00$0.00
May 1, 2026MCKENZIE DIANADirectorD796$0.00$0.00
May 1, 2026SACHS BRUCE IDirectorA2,866$0.00$0.00
May 1, 2026Schneider JenniferDirectorA472$0.00$0.00
May 1, 2026Schneider JenniferDirectorD796$0.00$0.00
May 1, 2026Schneider JenniferDirectorA1,433$0.00$0.00
May 1, 2026Schneider JenniferDirectorA796$0.00$0.00
May 1, 2026Thornberry NancyDirectorA472$0.00$0.00
May 1, 2026Thornberry NancyDirectorD398$0.00$0.00
May 1, 2026Thornberry NancyDirectorA1,433$0.00$0.00
May 1, 2026Thornberry NancyDirectorA398$0.00$0.00
May 1, 2026Bhatia Sangeeta N.DirectorA943$0.00$0.00
May 1, 2026Upadhyay SuketuDirectorD796$0.00$0.00
May 1, 2026Upadhyay SuketuDirectorA2,866$0.00$0.00
May 1, 2026Upadhyay SuketuDirectorA796$0.00$0.00
May 1, 2026CARNEY LLOYDDirectorA2,866$0.00$0.00
May 1, 2026Garber Alan MDirectorA472$0.00$0.00
May 1, 2026Garber Alan MDirectorA1,433$0.00$0.00
May 1, 2026Lagarde MichelDirectorA2,866$0.00$0.00
May 1, 2026Liu JoyEVP and Chief Legal OfficerSELL1,104$425.02$469.2K
Apr 15, 2026SACHS BRUCE IDirectorA107.345$442.50$47.5K
Apr 15, 2026Garber Alan MDirectorA33.898$442.50$15.0K
Apr 15, 2026Upadhyay SuketuDirectorA80.508$442.50$35.6K
Apr 1, 2026Liu JoyEVP and Chief Legal OfficerSELL978$449.17$439.3K
Mar 27, 2026Bozic CarmenEVP and CMOSELL2,329$450.95$1.1M
Mar 13, 2026Bozic CarmenEVP and CMOSELL2,329$481.79$1.1M
Mar 11, 2026McKechnie DuncanEVP, Chief Commercial OfficerSELL2,633$498.42$1.3M
Mar 4, 2026McKechnie DuncanEVP, Chief Commercial OfficerSELL2,437$475.30$1.2M
Mar 2, 2026Liu JoyEVP and Chief Legal OfficerSELL892$495.96$442.4K
Feb 27, 2026Bozic CarmenEVP and CMOSELL2,329$480.31$1.1M
Feb 27, 2026Kewalramani ReshmaCEO & PresidentSELL400$479.75$191.9K
Feb 25, 2026Tatsis OuraniaEVP, Chief Reg. & Quality Off.SELL260$486.35$126.5K
Feb 25, 2026Bunnage Mark E.EVP, Chief Scientific OfficerSELL620$486.35$301.5K
Feb 25, 2026Ambrose KristenSVP & Chief Accounting OfficerSELL223$486.35$108.5K
Feb 25, 2026Biller JonathanEVP and Chief Legal OfficerSELL945$486.35$459.6K
Feb 25, 2026Sachdev AmitEVP Chief Patient & Ext Af OffSELL1,846$486.35$897.8K
Feb 25, 2026Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off.SELL668$486.35$324.9K
Feb 25, 2026McKechnie DuncanEVP, Chief Commercial OfficerSELL2,500$486.35$1.2M
Feb 24, 2026WAGNER CHARLES F JREVP, CO & FOF1,744$485.11$846.0K
Feb 24, 2026Bunnage Mark E.EVP, Chief Scientific OfficerF582$485.11$282.3K
Feb 24, 2026Biller JonathanEVP and Chief Legal OfficerF1,144$485.11$555.0K
Feb 24, 2026Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off.F1,627$485.11$789.3K
10 SEC filing reports analyzed. Sentiment: 1 bullish, 1 bearish, 1 mixed, 7 neutral. Avg impact: 2.9/10.
MIXED ANALYST-UPGRADE 1/10
Maxim Group upgrades VRTX to Buy, PT $575 (+35%) — cluster of 20 firms active on the name
May 1, 2026
BULLISH ANALYST-UPGRADE 1/10
20 firms acted on VRTX: Maxim Group, Jefferies, Oppenheimer, Barclays, RBC Capital, Bernstein, Wolfe Research, Morgan Stanley, Leerink Partners, Raymond James, Wells Fargo, Leerink Partners, Canaccord Genuity, Wells Fargo, Oppenheimer, Jefferies, Citigroup, Scotiabank, Barclays, Redburn Atlantic
May 31, 2026
NEUTRAL CLUSTER 2/10
Two senior executives at Vertex Pharmaceuticals (EVP/CMO and EVP/Chief Legal Officer) sold a combine
Jun 3, 2026
NEUTRAL CLUSTER 2/10
Two EVP-level insiders at Vertex (CMO and Chief Scientific Officer) sold open-market shares on the s
May 19, 2026
NEUTRAL CLUSTER 3/10
Two Vertex Pharmaceuticals EVPs — the Chief Medical Officer and Chief Commercial Officer — sold shar
Mar 17, 2026
NEUTRAL CLUSTER 4/10
Two Vertex Pharmaceuticals EVPs — the Chief Commercial Officer and Chief Legal Officer — sold shares
Mar 6, 2026
BEARISH CLUSTER 6/10
Three senior executives at Vertex Pharmaceuticals — including the CEO and two EVPs — sold shares in
Mar 4, 2026
NEUTRAL CLUSTER 3/10
Seven executives at Vertex Pharmaceuticals sold shares in a coordinated cluster over a 3-day window,
Mar 3, 2026
NEUTRAL CLUSTER 4/10
Seven Vertex Pharmaceuticals executives sold shares in the past week, including open-market sales to
Feb 26, 2026
NEUTRAL CLUSTER 3/10
Two executives at Vertex Pharmaceuticals executed open-market share sales totaling $433K, while the
Feb 26, 2026

No press releases analyzed yet. Press releases are collected from GlobeNewsWire and analyzed by the LLM pipeline.

Current analyst consensus: Strong Buy (83% buy). Based on 40 analysts: 13 strong buy, 20 buy, 6 hold, 0 sell, 1 strong sell.

Analyst Price Targets

$548.69 mean target +23.1% upside Strong Buy (1.61)
$330.00 Low $641.00 High
MetricValue
Current Price$445.77
Target Low$330.00
Target Mean$548.69
Target Median$555.00
Target High$641.00
# Analysts29
RecommendationStrong Buy (1.61)

Earnings Estimates & Revisions

PeriodEPS AvgEPS LowEPS HighEPS Growth30d Rev.Up/DownRev. AvgRev. GrowthAnalysts
Current Q
2026-06-30
$4.73 $4.26 $5.16 4.6% +0.3% 9↑ 9↓ $3.2B 8.4% 24
Next Q
2026-09-30
$4.95 $4.69 $5.60 3.1% +0.3% 7↑ 10↓ $3.3B 8.8% 23
Current FY
2026-12-31
$19.15 $18.42 $20.73 4.1% -0.1% 14↑ 10↓ $13.0B 8.6% 28
Next FY
2027-12-31
$21.47 $18.77 $24.64 12.1% -0.4% 8↑ 14↓ $14.3B 9.4% 27

Current Quarter EPS Revision History

TimepointEPS EstimateChange
Current$4.727
7d ago$4.727
30d ago$4.715+0.012
60d ago$4.733-0.007
90d ago$4.741-0.014
18 analyst firms have rated this stock: 6 upgrades, 0 downgrades, 1 initiations.

Individual Analyst Actions

DateAnalyst FirmActionPrevious RatingNew Rating
May 6, 2026 Barclays MAINTAIN Overweight Overweight
May 5, 2026 Canaccord Genuity MAINTAIN Hold Hold
May 5, 2026 Morgan Stanley MAINTAIN Overweight Overweight
May 5, 2026 Bernstein MAINTAIN Outperform Outperform
May 5, 2026 RBC Capital MAINTAIN Outperform Outperform
Apr 30, 2026 Canaccord Genuity MAINTAIN Hold Hold
Apr 10, 2026 Morgan Stanley MAINTAIN Overweight Overweight
Mar 18, 2026 Maxim Group UPGRADE Hold Buy
Mar 11, 2026 Truist Securities MAINTAIN Buy Buy
Mar 10, 2026 Morgan Stanley MAINTAIN Overweight Overweight
Mar 10, 2026 B of A Securities MAINTAIN Buy Buy
Mar 10, 2026 Citigroup MAINTAIN Buy Buy
Mar 10, 2026 Oppenheimer MAINTAIN Outperform Outperform
Mar 10, 2026 Jefferies INITIATE Buy
Mar 10, 2026 HC Wainwright & Co. MAINTAIN Buy Buy
Feb 17, 2026 Canaccord Genuity MAINTAIN Hold Hold
Feb 17, 2026 Barclays MAINTAIN Overweight Overweight
Feb 17, 2026 HC Wainwright & Co. MAINTAIN Buy Buy
Feb 13, 2026 Scotiabank MAINTAIN Sector Perform Sector Perform
Feb 13, 2026 RBC Capital MAINTAIN Outperform Outperform
Feb 13, 2026 Stifel MAINTAIN Hold Hold
Feb 13, 2026 Oppenheimer UPGRADE Perform Outperform
Feb 13, 2026 HC Wainwright & Co. MAINTAIN Buy Buy
Jan 28, 2026 Barclays UPGRADE Equal-Weight Overweight
Jan 26, 2026 UBS MAINTAIN Buy Buy
Jan 23, 2026 Evercore ISI Group MAINTAIN Outperform Outperform
Jan 22, 2026 RBC Capital UPGRADE Sector Perform Outperform
Jan 12, 2026 Bernstein UPGRADE Market Perform Outperform
Jan 6, 2026 Wolfe Research UPGRADE Peer Perform Outperform
Dec 29, 2025 Leerink Partners MAINTAIN Outperform Outperform

Monthly Consensus History

PeriodStrong BuyBuyHoldSellStrong SellBuy %Distribution
Jun 1, 2026132060183%
May 1, 2026131960182%
Apr 1, 2026132060183%
Mar 1, 2026121970179%
Feb 1, 2026111980177%
Jan 1, 2026917120167%
Dec 1, 2025916130164%
Nov 1, 2025916130164%
Strong BuyBuyHoldSellStrong Sell
1 members of Congress traded this stock: 1 buys, 0 sells.

Congressional Trades

DateMemberPartyChamberTypeAmountAssetDisclosed
Apr 13, 2026Ro KhannaDHOUSEBUY$1,001 - $15,000Vertex Pharmaceuticals IncMay 13, 2026 (31d)

No Reddit sentiment data available yet. Sentiment is analyzed from Reddit investment communities on a rolling basis.

Aug 3, 2026
earnings_calendar
VRTX Q2 2026 Earnings After Market Close — 2026-08-03
EPS est: $4.85 | Rev est: $3.3B
May 29, 2026
Clinical Trial
A Study Evaluating Efficacy and Safety of VX-993 for Acute Pain After a Bunionectomy
Phase Phase 2 — COMPLETED
May 18, 2026
dark_pool
Dark Pool: VRTX — 2.4M shares, 63,833 trades
Week starting 2026-05-18. Total ATS volume: 2,422,905 shares across 63,833 trades.
May 12, 2026
short_volume
Short Volume: VRTX — 61.2% short (0.3M / 0.5M)
Short: 324,565 | Exempt: 317 | TRF Vol: 530,396 | Short Ratio: 61.2% | Off-exchange volume (dark pool + OTC)
May 11, 2026
dark_pool
Dark Pool: VRTX — 1.5M shares, 60,114 trades
Week starting 2026-05-11. Total ATS volume: 1,529,673 shares across 60,114 trades.
May 5, 2026
short_volume
Short Volume: VRTX — 63.3% short (0.5M / 0.8M)
Short: 489,189 | Exempt: 2,246 | TRF Vol: 773,330 | Short Ratio: 63.3% | Off-exchange volume (dark pool + OTC)
May 4, 2026
earnings_calendar
VRTX Q1 2026 Earnings After Market Close — 2026-05-04
EPS est: $4.53 | Rev est: $3.1B
May 4, 2026
earnings_calendar
VRTX Q1 2026 Earnings Scheduled — 2026-05-04
May 4, 2026
short_volume
Short Volume: VRTX — 57.7% short (0.3M / 0.6M)
Short: 343,481 | Exempt: 12,088 | TRF Vol: 595,055 | Short Ratio: 57.7% | Off-exchange volume (dark pool + OTC)
May 4, 2026
dark_pool
Dark Pool: VRTX — 1.7M shares, 64,650 trades
Week starting 2026-05-04. Total ATS volume: 1,683,411 shares across 64,650 trades.
Apr 27, 2026
dark_pool
Dark Pool: VRTX — 1.3M shares, 57,485 trades
Week starting 2026-04-27. Total ATS volume: 1,321,612 shares across 57,485 trades.
Apr 24, 2026
short_interest
FTD: VRTX — 1,290 shares ($0.6M) failed to deliver
Settlement: 20260424, Price: $435.10, FTD Value: $561,279, VERTEX PHARMACEUTICALS INC
Apr 20, 2026
dark_pool
Dark Pool: VRTX — 1.1M shares, 42,363 trades
Week starting 2026-04-20. Total ATS volume: 1,053,093 shares across 42,363 trades.
Apr 16, 2026
short_interest
FTD: VRTX — 2,143 shares ($0.9M) failed to deliver
Settlement: 20260416, Price: $441.70, FTD Value: $946,563.1, VERTEX PHARMACEUTICALS INC
Apr 15, 2026
short_volume
Short Volume: VRTX — 62.7% short (0.4M / 0.6M)
Short: 353,036 | Exempt: 422 | TRF Vol: 563,065 | Short Ratio: 62.7% | Off-exchange volume (dark pool + OTC)
Apr 13, 2026
dark_pool
Dark Pool: VRTX — 1.6M shares, 62,406 trades
Week starting 2026-04-13. Total ATS volume: 1,624,504 shares across 62,406 trades.
Apr 1, 2026
Clinical Trial
Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis (CF) Participants 2 Years and Older
Phase Phase 3 — COMPLETED
Mar 17, 2026
FDA
ALYFTREK
Supplemental Approval — Labeling — VANZACAFTOR, TEZACAFTOR, AND DEUTIVACAFTOR — TABLET — ORAL
Mar 17, 2026
FDA
ALYFTREK
Supplemental Approval — Labeling — VANZACAFTOR, TEZACAFTOR, AND DEUTIVACAFTOR — TABLET — ORAL
Mar 3, 2026
Clinical Trial
Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Transfusion-Dependent β-Thalassemia (TDT)
Phase Phase 3 — ACTIVE_NOT_RECRUITING
Feb 28, 2026
Clinical Trial
A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes
Phase Phase 2 — ACTIVE_NOT_RECRUITING
Sep 25, 2025
FDA
SYMDEKO (COPACKAGED)
Supplemental Approval — Labeling — TEZACAFTOR AND IVACAFTOR — TABLET
Sep 25, 2025
FDA
ORKAMBI
Supplemental Approval — Labeling — LUMACAFTOR AND IVACAFTOR — GRANULE — ORAL
Sep 25, 2025
FDA
TRIKAFTA (COPACKAGED)
Supplemental Approval — Labeling — ELEXACAFTOR, TEZACAFTOR, AND IVACAFTOR — GRANULES